PMID- 26918839
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20160404
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 147
DP  - 2016 May
TI  - Monthly variation in faeces:blood concentration ratio of persistent organic 
      pollutants over the first year of life: a case study of one infant.
PG  - 259-68
LID - S0013-9351(16)30059-7 [pii]
LID - 10.1016/j.envres.2016.02.017 [doi]
AB  - Previous studies have found that the concentrations of a range of persistent 
      organic pollutants (POPs) in faeces is linearly proportional to the POP 
      concentrations in blood of human adults irrespective of age and gender. In order 
      to investigate the correlation between POP concentrations in faeces and blood in 
      infants, the monthly variation of POP concentrations in faeces over the first 
      year of life of one infant was investigated in this study and compared to 
      modelled blood concentrations. Faecal samples were collected from one male infant 
      daily. The samples were pooled by month and analysed for three selected POPs 
      (2,2('),4,4('),5,5(')-Hexachlorobiphenyl (PCB153), 
      p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and 
      2,2('),4,4'-tetrabromodiphenyl ether (BDE47)). The POP concentrations in faecal 
      samples increased for the first four months by a factor of 2.9, 4.9 and 1.4 for 
      PCB153, BDE47, and p,p'-DDE, respectively. The faecal concentrations of all POPs 
      decreased rapidly following the introduction of formula and solid food to the 
      diet and subsequent weaning of the infant. Further, a one-compartment model was 
      developed to estimate the daily POP concentrations in the blood of the infant. 
      The POP concentrations in blood were predicted to vary much less over the first 
      year than those observed in faeces. The faeces:blood concentration ratio of 
      selected POPs (Kfb) differed significantly (P<0.0001) between the period before 
      and after weaning, and observed changes in Kfb are far greater than the 
      uncertainty in the estimated Kfb. A more stable Kfb after weaning indicates the 
      possibility of applying the stable Kfb values for non-invasive assessment of 
      internal exposure in infants after weaning. The intra-individual variation in Kfb 
      in infants is worthy of further investigation.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Chen, Yiqin
AU  - Chen Y
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia. Electronic address: y.chen16@uq.edu.au.
FAU - McLachlan, Michael S
AU  - McLachlan MS
AD  - Department of Environmental Science and Analytical Chemistry (ACES), Stockholm 
      University, Sweden.
FAU - Kaserzon, Sarit
AU  - Kaserzon S
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
FAU - Wang, Xianyu
AU  - Wang X
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
FAU - Weijs, Liesbeth
AU  - Weijs L
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
FAU - Gallen, Michael
AU  - Gallen M
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
FAU - Toms, Leisa-Maree L
AU  - Toms LM
AD  - School of Public Health and Social Work and Institute of Health and Biomedical 
      Innovation, Faculty of Health, Queensland University of Technology, Australia.
FAU - Li, Yan
AU  - Li Y
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
FAU - Aylward, Lesa L
AU  - Aylward LL
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia; Summit Toxicology, LLP, Falls Church, VA, USA.
FAU - Sly, Peter D
AU  - Sly PD
AD  - Children's Health and Environment Program, Queensland Children's Medical Research 
      Institute, Brisbane, Australia; Child Health Research Centre, The University of 
      Queensland, Australia.
FAU - Mueller, Jochen F
AU  - Mueller JF
AD  - The University of Queensland, National Research Centre for Environmental 
      Toxicology, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160223
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Dichlorodiphenyl Dichloroethylene/analysis/*blood
MH  - Environmental Pollutants/analysis/*blood
MH  - Feces/*chemistry
MH  - Halogenated Diphenyl Ethers/analysis/*blood
MH  - Humans
MH  - Infant
MH  - Kinetics
MH  - Male
MH  - Milk, Human/*chemistry
MH  - Models, Theoretical
MH  - Polychlorinated Biphenyls/analysis/*blood
MH  - Predictive Value of Tests
OTO - NOTNLM
OT  - Faeces:blood concentration ratio
OT  - Infant
OT  - Model
OT  - Noninvasive bio-monitoring
OT  - POPs
EDAT- 2016/02/27 06:00
MHDA- 2016/08/16 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/11/18 00:00 [received]
PHST- 2016/02/11 00:00 [revised]
PHST- 2016/02/13 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - S0013-9351(16)30059-7 [pii]
AID - 10.1016/j.envres.2016.02.017 [doi]
PST - ppublish
SO  - Environ Res. 2016 May;147:259-68. doi: 10.1016/j.envres.2016.02.017. Epub 2016 
      Feb 23.