PMID- 26918872
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20240324
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Print)
IS  - 0885-3177 (Linking)
VI  - 45
IP  - 4
DP  - 2016 Apr
TI  - Early Alterations in Glycemic Control and Pancreatic Endocrine Function in 
      Nondiabetic Patients With Chronic Pancreatitis.
PG  - 565-71
LID - 10.1097/MPA.0000000000000491 [doi]
AB  - OBJECTIVES: Diabetes mellitus is a frequent consequence of chronic pancreatitis 
      (CP). Little is known about pancreatic endocrine function before the development 
      of diabetes mellitus in CP, particularly in females, or those without calcific 
      and/or alcoholic pancreatitis. METHODS: Twenty-five nondiabetic adult patients 
      with CP (19 female; mean [SE] age, 34.2 [2.4] years) were compared with 25 
      healthy controls matched for age, sex, and body mass index. Subjects underwent 
      frequent sample intravenous glucose tolerance testing (FSIVGTT) and mixed meal 
      tolerance testing (MMTT). RESULTS: Mean (SE) fasting glucose was higher in 
      patients with CP (89.5 [2.3] mg/dL) than in controls (84.4 [1.2] mg/dL, P = 
      0.04). On MMTT, patients with CP had a higher area under the curve (AUC) glucose 
      and AUC glucagon compared with controls (P </= 0.01). The AUC C-peptide was 
      equivalent (P = 0.6) but stimulated C-peptide at 30 minutes was lower in patients 
      with CP (P = 0.04). Mean insulin sensitivity index calculated from the FSIVGTT 
      was lower in CP group, indicating reduced insulin sensitivity (P </= 0.01). 
      Disposition index (insulin secretion adjusted for insulin sensitivity on FSIVGTT) 
      was lower in patients with CP (P = 0.01). CONCLUSIONS: Patients with CP had 
      higher fasting and MMTT glucose levels, without a compensatory increase in 
      insulin secretion suggesting subtle early islet dysfunction. Our cohort had 
      relative hyperglucagonemia and was less insulin sensitive than controls.
FAU - Lundberg, Rachel
AU  - Lundberg R
AD  - From the Departments *Pediatrics, daggerSurgery, and double daggerMedicine, University of 
      Minnesota, Minneapolis, MN.
FAU - Beilman, Gregory J
AU  - Beilman GJ
FAU - Dunn, Ty B
AU  - Dunn TB
FAU - Pruett, Tim L
AU  - Pruett TL
FAU - Freeman, Martin L
AU  - Freeman ML
FAU - Ptacek, Peggy E
AU  - Ptacek PE
FAU - Berry, Katherine Louise
AU  - Berry KL
FAU - Robertson, R Paul
AU  - Robertson RP
FAU - Moran, Antoinette
AU  - Moran A
FAU - Bellin, Melena D
AU  - Bellin MD
LA  - eng
GR  - K23 DK084315/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000114/TR/NCATS NIH HHS/United States
GR  - 1K23DK084315/DK/NIDDK NIH HHS/United States
GR  - R01-39994/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - C-Peptide/blood
MH  - Diabetes Mellitus/blood/diagnosis/physiopathology
MH  - Disease Progression
MH  - Fasting/blood
MH  - Female
MH  - Glucagon/blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood/metabolism
MH  - Insulin Secretion
MH  - Islets of Langerhans/*physiopathology
MH  - Male
MH  - Pancreatitis, Chronic/*blood/*physiopathology
PMC - PMC4783201
MID - NIHMS712274
COIS- Conflict of Interest Disclosure: The authors declare no conflict of interest.
EDAT- 2016/02/27 06:00
MHDA- 2016/12/15 06:00
PMCR- 2017/05/01
CRDT- 2016/02/27 06:00
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - 10.1097/MPA.0000000000000491 [doi]
PST - ppublish
SO  - Pancreas. 2016 Apr;45(4):565-71. doi: 10.1097/MPA.0000000000000491.