PMID- 26919285
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20220408
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 43
IP  - 9
DP  - 2016 May
TI  - Cardiac volume overload and pulmonary hypertension in long-term follow-up of 
      patients with a transjugular intrahepatic portosystemic shunt.
PG  - 955-65
LID - 10.1111/apt.13569 [doi]
AB  - BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPSS) cause 
      haemodynamic changes in patients with cirrhosis, yet little is known about 
      long-term cardiopulmonary outcomes. AIM: To evaluate the long-term 
      cardiopulmonary outcome after TIPSS. METHODS: We evaluated cardiopulmonary 
      parameters including echocardiography during long-term follow-up after TIPSS. 
      Results at 1-5 years after TIPSS were compared to those of cirrhotic controls. 
      Pulmonary hypertension (PH) diagnoses rates were included. Endothelin 1, 
      thromboxane B2 and serotonin were measured. RESULTS: We found significant 
      differences 1-5 years after TIPSS compared to pre-implantation values: median 
      left atrial diameter (LAD) increased from 37 mm [interquartile range (IQR): 
      33-43] to 40 mm (IQR: 37-47, P = 0.001), left ventricular end-diastolic diameter 
      (LV-EDD) increased from 45 mm (range: 41-49) to 48 mm (IQR: 45-52, P < 0.001), 
      pulmonary artery systolic pressure (PASP) increased from 25 mmHg (IQR: 22-33) to 
      30 mmHg (IQR: 25-36, P = 0.038). Comparing results 1-5 years post-implantation to 
      the comparison cohort revealed significantly higher (P < 0.05) LAD, LV-EDD and 
      PASP values in TIPSS patients. PH prevalence was higher in the shunt group 
      (4.43%) compared to controls (0.91%, P = 0.150). Thromboxane B2 levels correlated 
      with PASP in the TIPSS cohort (P = 0.033). There was no transhepatic gradient 
      observed for the vasoactive substances analysed. CONCLUSIONS: TIPSS placement is 
      accompanied by long-term cardiovascular changes, including cardiac volume 
      overload, and is associated with an increased rate of pulmonary hypertension. The 
      need for regular cardiac follow-up after TIPSS requires further evaluation.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Wannhoff, A
AU  - Wannhoff A
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Hippchen, T
AU  - Hippchen T
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Weiss, C S
AU  - Weiss CS
AD  - Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Friedrich, K
AU  - Friedrich K
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Rupp, C
AU  - Rupp C
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Neumann-Haefelin, C
AU  - Neumann-Haefelin C
AD  - Department of Medicine II, Freiburg University Medical Center, University of 
      Freiburg, Freiburg, Germany.
FAU - Dollinger, M
AU  - Dollinger M
AD  - Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
FAU - Antoni, C
AU  - Antoni C
AD  - Department of Medicine II, Heidelberg University Hospital at Mannheim, Mannheim, 
      Germany.
FAU - Stampfl, U
AU  - Stampfl U
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Heidelberg, Heidelberg, Germany.
FAU - Schemmer, P
AU  - Schemmer P
AD  - Department of General Visceral and Transplant Surgery, University Hospital 
      Heidelberg, Heidelberg, Germany.
FAU - Stremmel, W
AU  - Stremmel W
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Weiss, K H
AU  - Weiss KH
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Radeleff, B
AU  - Radeleff B
AD  - Department of Diagnostic and Interventional Radiology, University Hospital 
      Heidelberg, Heidelberg, Germany.
FAU - Katus, H A
AU  - Katus HA
AD  - Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, 
      Germany.
FAU - Gotthardt, D N
AU  - Gotthardt DN
AD  - Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160226
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Endothelin-1)
RN  - 333DO1RDJY (Serotonin)
RN  - 54397-85-2 (Thromboxane B2)
SB  - IM
CIN - Aliment Pharmacol Ther. 2016 Jun;43(11):1233-5. PMID: 27137723
CIN - Aliment Pharmacol Ther. 2016 Jun;43(11):1235. PMID: 27137724
CIN - Aliment Pharmacol Ther. 2016 Aug;44(4):422-3. PMID: 27412996
CIN - Aliment Pharmacol Ther. 2016 Aug;44(4):423-4. PMID: 27412997
MH  - Adult
MH  - Cardiac Volume/*physiology
MH  - Endothelin-1/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Liver Cirrhosis/*therapy
MH  - Male
MH  - Middle Aged
MH  - Portasystemic Shunt, Transjugular Intrahepatic/*adverse effects/methods
MH  - Serotonin/metabolism
MH  - Thromboxane B2/metabolism
EDAT- 2016/02/27 06:00
MHDA- 2016/10/25 06:00
CRDT- 2016/02/27 06:00
PHST- 2015/06/05 00:00 [received]
PHST- 2015/06/28 00:00 [revised]
PHST- 2015/12/29 00:00 [revised]
PHST- 2016/02/03 00:00 [revised]
PHST- 2016/02/04 00:00 [accepted]
PHST- 2016/02/27 06:00 [entrez]
PHST- 2016/02/27 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - 10.1111/apt.13569 [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2016 May;43(9):955-65. doi: 10.1111/apt.13569. Epub 2016 
      Feb 26.