PMID- 26919830
OWN - NLM
STAT- MEDLINE
DCOM- 20180619
LR  - 20221207
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 23
IP  - 6
DP  - 2017 Jun
TI  - Association between genetic variants and characteristic symptoms of type 2 
      diabetes: A matched case-control study.
PG  - 415-424
LID - 10.1007/s11655-015-2290-3 [doi]
AB  - OBJECTIVE: To examine the association of genetic variants with characteristic 
      symptoms of type 2 diabetes mellitus (T2DM). METHODS: A matched case-control 
      study was performed to investigate the association between common variants in 
      four genes (CDKAL1, GLIS3, GRK5, and TCF7L2) and symptoms of T2DM. Symptoms were 
      examined with questionnaire for 710 subjects. Genomic DNA was extracted from 
      peripheral blood mononuclear cell by salting-out procedure. Genotyping was 
      carried out by direct sequencing of the unpurified polymerase chain reaction 
      products. RESULT: Most of the T2DM patients pressented characteristic symptoms, 
      such as feeling weak in limbs (P =0.0057), hand tremor (P =0.0208), bradymasesis 
      (P =0.0234), and polyuria (P =0.0051). Some of the T2DM patients shared 
      characteristic symptoms, such as desire for cold drinks (P =0.0304), polyphagia 
      (P =0.0051), and furred tongue (P =0.028). The impaired glucose regulation (IGR) 
      cases took only one characteristic symptom of frequent micturition (P =0.0422). 
      GLIS3 rs7034200 and GRK5 rs10886471 were significantly associated with increased 
      T2DM risk (GLIS3 rs7034200 under dominant model: P=0.0307; GRK5 rs10886471 under 
      recessive model: P=0.0092). However, only the rs10886471 polymorphism in GRK5 
      showed a significant effect on both differentiated symptoms and T2DM risk. The 
      C-allele was involved in both dampness-heat encumbering Pi (Spleen) syndrome (P 
      =0.047) and qi-yin deficiency syndrome (P =0.002) via increased GRK5 expression. 
      CONCLUSIONS: Both T2DM and IGR exhibited its corresponding characteristic 
      symptoms. The variants of GRK5 were involved with both qi-yin deficiency syndrome 
      and dampness-heat encumbering Pi syndrome.
FAU - Dou, Hao-Ying
AU  - Dou HY
AD  - Department of Nursing, Tianjin University of Traditional Chinese Medicine, 
      Tianjin, 300193, China.
FAU - Wang, Yuan-Yuan
AU  - Wang YY
AD  - Department of Nursing, Tianjin University of Traditional Chinese Medicine, 
      Tianjin, 300193, China.
FAU - Yang, Nan
AU  - Yang N
AD  - Department of Nursing, Tianjin University of Traditional Chinese Medicine, 
      Tianjin, 300193, China.
FAU - Heng, Ming-Li
AU  - Heng ML
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China.
FAU - Zhou, Xuan
AU  - Zhou X
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China.
FAU - Bu, Huai-En
AU  - Bu HE
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China.
FAU - Xu, Fang
AU  - Xu F
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China.
FAU - Zhao, Tie-Niu
AU  - Zhao TN
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China.
FAU - Huang, He
AU  - Huang H
AD  - Department of Biochemical Engineering, School of Chemical Engineering and 
      Technology, Key Laboratory of Systems Bioengineering, Ministry of Education, 
      Tianjin University, Tianjin, 300072, China.
FAU - Wang, Hong-Wu
AU  - Wang HW
AD  - Department of Traditional Chinese Medicine, Tianjin University of Traditional 
      Chinese Medicine, Tianjin, 300193, China. wanghongwu55@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Syndrome
OTO - NOTNLM
OT  - Chinese medicine
OT  - genetic variants
OT  - impaired glucose regulation
OT  - syndromes
OT  - type 2 diabetes mellitus
EDAT- 2016/02/28 06:00
MHDA- 2018/06/21 06:00
CRDT- 2016/02/28 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2016/02/28 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2016/02/28 06:00 [entrez]
AID - 10.1007/s11655-015-2290-3 [pii]
AID - 10.1007/s11655-015-2290-3 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2017 Jun;23(6):415-424. doi: 10.1007/s11655-015-2290-3. Epub 
      2016 Feb 26.