PMID- 26919951
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160227
LR  - 20180219
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 9
IP  - 2
DP  - 2016 Feb
TI  - Association of CT perfusion imaging with plasma levels of TGF-beta1 and VEGF in 
      patients with NSCLC.
PG  - 177-9
LID - S1995-7645(16)00010-9 [pii]
LID - 10.1016/j.apjtm.2016.01.009 [doi]
AB  - OBJECTIVE: To study the association of CT perfusion imaging parameters with 
      plasma level of transforming growth factor-beta1 (TGF-beta1) and vascular endothelial 
      growth (VEGF) in patients with non small cell lung cancer (NSCLC). METHODS: A 
      total of 67 patients with NSCLC (NSCLC group) and 64 patients with benign lesion 
      (control group) were given with CT perfusion imaging to obtain blood flow, blood 
      volume, mean transit time, time to peal and permeability surface through CT 
      perfusion software. The plasma levels of TGF-beta1 and VEGF were tested by ELISA. 
      The relationship between plasma levels of TGF-beta1, VEGF and CT perfusion imaging 
      parameters were analyzed. RESULTS: CT perfusion imaging parameters and the plasma 
      levels of TGF-beta1 and VEGF of NSCLC group were significantly higher than the 
      control group (P < 0.05), while CT perfusion parameters and the levels of TGF-beta1 
      and VEGF in NSCLC group showed significant difference in different tumor node 
      metastasis stages (P < 0.05). Correlation analysis showed that the level of 
      plasma TGF-beta1 and VEGF were positively correlated with blood flow, blood volume, 
      and mean transit time (P < 0.05), and negatively correlated with time to peal 
      (P < 0.05). There was no significant correlation between TGF-beta1 and VEGF with the 
      permeability surface. CONCLUSIONS: CT perfusion imaging parameters in patients 
      with NSCLC is closely associated with plasma TGF-beta1, VEGF and its biological 
      characteristics. CT perfusion imaging is a convenient method to detect tumor 
      blood perfusion.
CI  - Copyright (c) 2016 Hainan Medical College. Production and hosting by Elsevier B.V. 
      All rights reserved.
FAU - Li, Da-Wei
AU  - Li DW
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China.
FAU - Wu, Bao-Zhong
AU  - Wu BZ
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China.
FAU - Shi, Yu-Sen
AU  - Shi YS
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China. Electronic address: hksys2005@163.com.
FAU - Li, Zhi-Qun
AU  - Li ZQ
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China.
FAU - Liu, Xu-Dong
AU  - Liu XD
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China.
FAU - Li, Xiao-Hua
AU  - Li XH
AD  - Radiology Department, Affiliated Hospital of Hainan Medical College, Hainan, 
      Haikou 570102, China.
LA  - eng
PT  - Journal Article
DEP - 20160111
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
OTO - NOTNLM
OT  - CT perfusion parameters
OT  - Non small cell lung cancer
OT  - Transforming growth factor-beta1
OT  - Vascular endothelial growth
EDAT- 2016/02/28 06:00
MHDA- 2016/02/28 06:01
CRDT- 2016/02/28 06:00
PHST- 2015/11/15 00:00 [received]
PHST- 2015/12/20 00:00 [revised]
PHST- 2015/12/30 00:00 [accepted]
PHST- 2016/02/28 06:00 [entrez]
PHST- 2016/02/28 06:00 [pubmed]
PHST- 2016/02/28 06:01 [medline]
AID - S1995-7645(16)00010-9 [pii]
AID - 10.1016/j.apjtm.2016.01.009 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2016 Feb;9(2):177-9. doi: 10.1016/j.apjtm.2016.01.009. Epub 
      2016 Jan 11.