PMID- 26920939
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 31
IP  - 12
DP  - 2016 Dec
TI  - Clinical significance of endomyocardial biopsy in conjunction with cardiac 
      magnetic resonance imaging to predict left ventricular reverse remodeling in 
      idiopathic dilated cardiomyopathy.
PG  - 1960-1968
AB  - Endomyocardial biopsy (EMB) and cardiac magnetic resonance (CMR) are useful 
      modalities to study the characteristics of myocardial tissue. However, the 
      prognostic impact of both diagnostic tools to predict subsequent left ventricular 
      reverse remodeling (LVRR) has not been well elucidated. A total of 187 
      consecutive patients with idiopathic dilated cardiomyopathy (IDCM) who were 
      treated by optimal pharmacotherapy (OPT) and underwent EMB of the LV wall were 
      investigated. The myocardial specimens were semiquantitatively evaluated 
      measuring cardiomyocyte degeneration (CD), interstitial fibrosis (IF), and 
      hypertrophy. In addition, late gadolinium enhancement (LGE)-CMR was performed in 
      78 (48 %) patients. Seventy-eight (48 %) patients developed LVRR, defined as a 
      >/=10 % increase in LV ejection fraction with a >/=10 % decrease in indexed LV 
      end-diastolic dimension at 12 months after OPT. Multivariate regression analysis 
      revealed that CD (P = 0.003), but not IF (P = 0.320), was an independent 
      predictor of LVRR. In the patients with not only EMB but also CMR, the CD score 
      and LGE area were independent predictors of LVRR (odds ratios/P values 
      0.268/0.010, 0.855/<0.001, respectively). The patients with mild CD and negative 
      LGE had a better achievement rate of LVRR than those with severe CD and positive 
      LGE (74 vs. 19 %). A combination of CD score on EMB and LGE-CMR is useful to 
      predict subsequent LVRR in IDCM patients.
FAU - Ishii, Shunsuke
AU  - Ishii S
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. 
      sishii@med.kitasato-u.ac.jp.
FAU - Inomata, Takayuki
AU  - Inomata T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Fujita, Teppei
AU  - Fujita T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Iida, Yuichiro
AU  - Iida Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Ikeda, Yuki
AU  - Ikeda Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Nabeta, Takeru
AU  - Nabeta T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Yanagisawa, Tomoyoshi
AU  - Yanagisawa T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Naruke, Takashi
AU  - Naruke T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Mizutani, Tomohiro
AU  - Mizutani T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Koitabashi, Toshimi
AU  - Koitabashi T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Takeuchi, Ichiro
AU  - Takeuchi I
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Ako, Junya
AU  - Ako J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Biopsy
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/drug 
      therapy/*pathology/physiopathology
MH  - Cardiovascular Agents/therapeutic use
MH  - Chi-Square Distribution
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardium/*pathology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Ventricular Function, Left/drug effects
MH  - *Ventricular Remodeling/drug effects
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Endomycardial biopsy
OT  - Idiopathic dilated cardiomyopathy
OT  - Left ventricular reverse remodeling
EDAT- 2016/02/28 06:00
MHDA- 2018/02/06 06:00
CRDT- 2016/02/28 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2016/02/05 00:00 [accepted]
PHST- 2016/02/28 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2016/02/28 06:00 [entrez]
AID - 10.1007/s00380-016-0815-0 [pii]
AID - 10.1007/s00380-016-0815-0 [doi]
PST - ppublish
SO  - Heart Vessels. 2016 Dec;31(12):1960-1968. doi: 10.1007/s00380-016-0815-0. Epub 
      2016 Feb 26.