PMID- 26921590
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 150
DP  - 2016 May
TI  - Advances in in vitro methods to evaluate oral bioaccessibility of PAHs and PBDEs 
      in environmental matrices.
PG  - 378-389
LID - S0045-6535(16)30193-X [pii]
LID - 10.1016/j.chemosphere.2016.02.041 [doi]
AB  - Cleanup goals for sites contaminated with persistent organic pollutants (POPs) 
      are often established based on total contaminant concentrations. However, 
      mounting evidence suggests that understanding contaminant bioavailability in 
      soils is necessary for accurate assessment of contaminant exposure to humans via 
      oral ingestion pathway. Animal-based in vivo tests have been used to assess 
      contaminant bioavailability in soils; however, due to ethical issues and cost, it 
      is desirable to use in vitro assays as alternatives. Various in vitro methods 
      have been developed, which simulate human gastrointestinal (GI) tract using 
      different digestion fluids. These methods can be used to predict POP 
      bioavailability in soils, foods, and indoor dust after showing good correlation 
      with in vivo animal data. Here, five common in vitro methods are evaluated and 
      compared using PAHs and PBDEs as an example of traditional and emerging POPs. 
      Their applications and limitations are discussed while focusing on method 
      improvements and future challenges to predict POP bioavailability in different 
      matrices. The discussions should shed light for future research to accurately 
      assess human exposure to POPs via oral ingestion pathway.
CI  - Published by Elsevier Ltd.
FAU - Cui, Xin-Yi
AU  - Cui XY
AD  - State Key Lab of Pollution Control and Resource Reuse, School of the Environment, 
      Nanjing University, Jiangsu 210046, China.
FAU - Xiang, Ping
AU  - Xiang P
AD  - State Key Lab of Pollution Control and Resource Reuse, School of the Environment, 
      Nanjing University, Jiangsu 210046, China.
FAU - He, Rui-Wen
AU  - He RW
AD  - State Key Lab of Pollution Control and Resource Reuse, School of the Environment, 
      Nanjing University, Jiangsu 210046, China.
FAU - Juhasz, Albert
AU  - Juhasz A
AD  - Future Industries Institute, University of South Australia, Mawson Lakes, SA 
      5095, Australia.
FAU - Ma, Lena Q
AU  - Ma LQ
AD  - State Key Lab of Pollution Control and Resource Reuse, School of the Environment, 
      Nanjing University, Jiangsu 210046, China; Soil and Water Science Department, 
      University of Florida, Gainesville, FL 32611, USA. Electronic address: 
      lqma@ufl.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160226
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Dust)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Soil)
RN  - 0 (Soil Pollutants)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Computer Simulation
MH  - Dust/analysis
MH  - Environmental Exposure/*analysis
MH  - Food Chain
MH  - Food Contamination/analysis
MH  - Gastrointestinal Tract/metabolism
MH  - Halogenated Diphenyl Ethers/*analysis/metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - *Models, Biological
MH  - Polycyclic Aromatic Hydrocarbons/*analysis/metabolism
MH  - Soil/chemistry
MH  - Soil Pollutants/*analysis/metabolism
OTO - NOTNLM
OT  - Bioavailability
OT  - Gastrointestinal in vitro methods
OT  - Persistent organic pollutants (POPs)
OT  - Risk assessment
EDAT- 2016/02/28 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/28 06:00
PHST- 2015/06/20 00:00 [received]
PHST- 2016/01/05 00:00 [revised]
PHST- 2016/02/09 00:00 [accepted]
PHST- 2016/02/28 06:00 [entrez]
PHST- 2016/02/28 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0045-6535(16)30193-X [pii]
AID - 10.1016/j.chemosphere.2016.02.041 [doi]
PST - ppublish
SO  - Chemosphere. 2016 May;150:378-389. doi: 10.1016/j.chemosphere.2016.02.041. Epub 
      2016 Feb 26.