PMID- 26922089
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171102
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 17
IP  - 6
DP  - 2016 Jun
TI  - Pulmonary hypertension is associated with worse survival in hypertrophic 
      cardiomyopathy.
PG  - 604-10
LID - 10.1093/ehjci/jew024 [doi]
AB  - AIMS: Pulmonary hypertension (PH) is associated with increased mortality in 
      various forms of left-sided heart disease. However, the implications of PH in 
      hypertrophic cardiomyopathy (HCM) have not been elucidated. The objective of this 
      study was to determine the prevalence and prognostic implications of PH in HCM. 
      METHODS AND RESULTS: The study cohort consisted of 1570 (54 +/- 15 years; 53% male) 
      adults with HCM followed for a median of 3.3 years. PH [pulmonary artery systolic 
      pressure (PASP) >36 mmHg] was identified in 38% of patients who were older (57 +/- 
      15 vs. 52 +/- 15 years, P < 0.0001), more likely to be female (59 vs. 40%, P < 
      0.0001), and were characterized by a higher prevalence of New York Heart 
      Association (NYHA) class 3 or 4 symptoms (61 vs. 45%, P < 0.0001) and atrial 
      fibrillation (29 vs. 15%, P < 0.0001) vs. those without PH. Only 12% had moderate 
      or severe PH (PASP >50 mmHg). In multivariate Cox regression analyses adjusted 
      for age, sex, NYHA class 3 or 4 symptoms, and atrial fibrillation, PASP was an 
      independent predictor of all-cause mortality in patients with non-obstructive HCM 
      (HR 1.59 per 10 mmHg PASP increase, 95% CI 1.28-1.96, P < 0.0001) and in those 
      with obstructive physiology who did not undergo septal reduction therapy (SRT) 
      (HR 1.15 per 10 mmHg PASP, 95% CI 1.01-1.31, P = 0.035). However, PH was not 
      predictive of outcomes in patients with obstructive HCM who underwent SRT. 
      CONCLUSIONS: Over one-third of adults evaluated in our referral HCM clinic 
      demonstrated concomitant PH, and this was associated with increased mortality 
      except in those with obstructive HCM who underwent SRT.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2016. For permissions please email: journals.permissions@oup.com.
FAU - Ong, Kevin C
AU  - Ong KC
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA gersh.bernard@mayo.edu.
FAU - Geske, Jeffrey B
AU  - Geske JB
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Hebl, Virginia B
AU  - Hebl VB
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Nishimura, Rick A
AU  - Nishimura RA
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Schaff, Hartzell V
AU  - Schaff HV
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Ackerman, Michael J
AU  - Ackerman MJ
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Klarich, Kyle W
AU  - Klarich KW
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Siontis, Konstantinos C
AU  - Siontis KC
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Coutinho, Thais
AU  - Coutinho T
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Dearani, Joseph A
AU  - Dearani JA
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Ommen, Steve R
AU  - Ommen SR
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
FAU - Gersh, Bernard J
AU  - Gersh BJ
AD  - Division of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic 
      College of Medicine, Rochester, MN, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160227
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
CIN - Eur Heart J Cardiovasc Imaging. 2016 Jun;17 (6):611-2. PMID: 27076361
MH  - Adult
MH  - Aged
MH  - Cardiac Surgical Procedures/methods
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*epidemiology/surgery
MH  - Cause of Death
MH  - Cohort Studies
MH  - Comorbidity
MH  - *Echocardiography
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnostic imaging/*epidemiology/surgery
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Pulmonary Wedge Pressure
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Survival Analysis
OTO - NOTNLM
OT  - echocardiography
OT  - hypertrophic cardiomyopathy
OT  - pulmonary hypertension
OT  - surgery
OT  - survival
EDAT- 2016/02/29 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/02/29 06:00
PHST- 2015/11/04 00:00 [received]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/29 06:00 [entrez]
PHST- 2016/02/29 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - jew024 [pii]
AID - 10.1093/ehjci/jew024 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2016 Jun;17(6):604-10. doi: 10.1093/ehjci/jew024. 
      Epub 2016 Feb 27.