PMID- 26923065
OWN - NLM
STAT- MEDLINE
DCOM- 20180104
LR  - 20180104
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 56
DP  - 2016 Aug
TI  - Alteration of transcriptional networks in the entorhinal cortex after maternal 
      immune activation and adolescent cannabinoid exposure.
PG  - 187-96
LID - S0889-1591(16)30041-1 [pii]
LID - 10.1016/j.bbi.2016.02.021 [doi]
AB  - Maternal immune activation (MIA) and adolescent cannabinoid exposure (ACE) have 
      both been identified as major environmental risk factors for schizophrenia. We 
      examined the effects of these two risk factors alone, and in combination, on gene 
      expression during late adolescence. Pregnant rats were exposed to the viral 
      infection mimic polyriboinosinic-polyribocytidylic acid (poly I:C) on gestational 
      day (GD) 15. Adolescent offspring received daily injections of the cannabinoid 
      HU210 for 14days starting on postnatal day (PND) 35. Gene expression was examined 
      in the left entorhinal cortex (EC) using mRNA microarrays. We found prenatal 
      treatment with poly I:C alone, or HU210 alone, produced relatively minor changes 
      in gene expression. However, following combined treatments, offspring displayed 
      significant changes in transcription. This dramatic and persistent alteration of 
      transcriptional networks enriched with genes involved in neurotransmission, 
      cellular signalling and schizophrenia, was associated with a corresponding 
      perturbation in the expression of small non-coding microRNA (miRNA). These 
      results suggest that a combination of environmental exposures during development 
      leads to significant genomic remodeling that disrupts maturation of the EC and 
      its associated circuitry with important implications as the potential antecedents 
      of memory and learning deficits in schizophrenia and other neuropsychiatric 
      disorders.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Hollins, Sharon L
AU  - Hollins SL
AD  - School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, 
      University of Newcastle, Callaghan, NSW, Australia; Schizophrenia Research 
      Institute, Sydney, NSW, Australia; Centre for Brain and Mental Health Research, 
      Hunter Medical Research Institute, Newcastle, NSW 2305, Australia.
FAU - Zavitsanou, Katerina
AU  - Zavitsanou K
AD  - School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, 
      University of Newcastle, Callaghan, NSW, Australia.
FAU - Walker, Frederick Rohan
AU  - Walker FR
AD  - School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, 
      University of Newcastle, Callaghan, NSW, Australia; Centre for Brain and Mental 
      Health Research, Hunter Medical Research Institute, Newcastle, NSW 2305, 
      Australia.
FAU - Cairns, Murray J
AU  - Cairns MJ
AD  - School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, 
      University of Newcastle, Callaghan, NSW, Australia; Schizophrenia Research 
      Institute, Sydney, NSW, Australia; Centre for Brain and Mental Health Research, 
      Hunter Medical Research Institute, Newcastle, NSW 2305, Australia. Electronic 
      address: murray.cairns@newcastle.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Cannabinoid Receptor Agonists)
RN  - 7J8897W37S (Dronabinol)
RN  - O84C90HH2L (Poly I-C)
RN  - R6VT8U5372 (HU 211)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cannabinoid Receptor Agonists/administration & dosage/*pharmacology
MH  - Disease Models, Animal
MH  - Dronabinol/administration & dosage/analogs & derivatives/pharmacology
MH  - *Entorhinal Cortex/drug effects/immunology/metabolism
MH  - Female
MH  - *Gene Expression/drug effects/genetics/immunology
MH  - *Gene Regulatory Networks/drug effects/genetics/immunology
MH  - *Poly I-C/administration & dosage
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/immunology
MH  - Rats
MH  - Rats, Wistar
MH  - *Virus Diseases/immunology
OTO - NOTNLM
OT  - Brain
OT  - Cannabinoid
OT  - Entorhinal cortex
OT  - Gene expression
OT  - Maternal infection
OT  - Schizophrenia
EDAT- 2016/03/01 06:00
MHDA- 2018/01/05 06:00
CRDT- 2016/03/01 06:00
PHST- 2015/01/28 00:00 [received]
PHST- 2016/02/16 00:00 [revised]
PHST- 2016/02/24 00:00 [accepted]
PHST- 2016/03/01 06:00 [entrez]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2018/01/05 06:00 [medline]
AID - S0889-1591(16)30041-1 [pii]
AID - 10.1016/j.bbi.2016.02.021 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2016 Aug;56:187-96. doi: 10.1016/j.bbi.2016.02.021. Epub 2016 
      Feb 26.