PMID- 26923421
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20170817
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 33
IP  - 7
DP  - 2016 Jul
TI  - Relation of Pulmonary Artery Pressure and Renal Impairment in ST Segment 
      Elevation Myocardial Infarction Patients.
PG  - 956-61
LID - 10.1111/echo.13206 [doi]
AB  - BACKGROUND: Recent reports have demonstrated the adverse effects of venous 
      congestion on renal function in patients having heart failure. None of the above 
      trials, however, included patients with acute ischemia. HYPOTHESIS: 
      Echocardiographic correlates of increased right ventricular afterload would be 
      associated with an increased risk of acute kidney injury (AKI) in ST elevation 
      myocardial infarction (STEMI) patients undergoing primary percutaneous coronary 
      intervention (PCI). METHODS: We conducted a retrospective study of consecutive 
      930 STEMI patients who underwent primary PCI and had a full echocardiography 
      study performed within 72 hours of hospital admission between June 2011 and 
      December 2014. RESULTS: Echocardiography demonstrated that patients with AKI had 
      significantly lower left ventricular (LV) ejection fraction, higher systolic 
      pulmonary artery pressure (SPAP), and right atrial pressures (P < 0.001 for all). 
      Following the performance of logistic multivariate analysis model, SPAP (HR 1.07, 
      95% CI 1.04-1.11; P < 0.001) and LV ejection fraction (HR 0.95, 95% CI 0.92-0.99; 
      P = 0.03) emerged as independent predictors of AKI. On receiver operating 
      characteristic (ROC) curve analysis, the optimal cutoff value of SPAP to predict 
      AKI was measured as more than 32 mmHg, with 71% sensitivity and 62% specificity 
      (AUC 0.739, 95% CI 0.671-0.806, P < 0.001). CONCLUSIONS: Among STEMI patients 
      undergoing primary PCI, worse LV function and elevated SPAP were associated with 
      increased risk of AKI.
CI  - (c) 2016, Wiley Periodicals, Inc.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Gal-Oz, Amir
AU  - Gal-Oz A
AD  - Department of Nephrology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Topilsky, Yan
AU  - Topilsky Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Keren, Gad
AU  - Keren G
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Arbel, Yaron
AU  - Arbel Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20160228
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Acute Kidney Injury/*diagnostic imaging/*epidemiology
MH  - Arterial Pressure
MH  - Causality
MH  - Comorbidity
MH  - Echocardiography/methods
MH  - Female
MH  - Humans
MH  - Israel/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Pulmonary Artery/diagnostic imaging/*physiopathology
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/*diagnostic 
      imaging/*epidemiology/physiopathology
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*epidemiology
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - acute kidney injury
OT  - percutaneous coronary intervention
OT  - pulmonary artery pressure
EDAT- 2016/03/01 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/03/01 06:00
PHST- 2016/03/01 06:00 [entrez]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
AID - 10.1111/echo.13206 [doi]
PST - ppublish
SO  - Echocardiography. 2016 Jul;33(7):956-61. doi: 10.1111/echo.13206. Epub 2016 Feb 
      28.