PMID- 26923584
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20170903
IS  - 2211-1247 (Electronic)
VI  - 14
IP  - 9
DP  - 2016 Mar 8
TI  - SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent 
      Fasting.
PG  - 2068-2075
LID - S2211-1247(16)30081-X [pii]
LID - 10.1016/j.celrep.2016.02.007 [doi]
AB  - Caloric restriction (CR) has been shown to prevent the onset of insulin 
      resistance and to delay age-related physiological decline in mammalian organisms. 
      SIRT1, a NAD(+)-dependent deacetylase enzyme, has been suggested to mediate the 
      adaptive responses to CR, leading to the speculation that SIRT1 activation could 
      be therapeutically used as a CR-mimetic strategy. Here, we used a mouse model of 
      moderate SIRT1 overexpression to test whether SIRT1 gain of function could mimic 
      or boost the metabolic benefits induced by every-other-day feeding (EODF). Our 
      results indicate that SIRT1 transgenesis does not affect the ability of EODF to 
      decrease adiposity and improve insulin sensitivity. Transcriptomic analyses 
      revealed that SIRT1 transgenesis and EODF promote very distinct adaptations in 
      individual tissues, some of which can be even be metabolically opposite, as in 
      brown adipose tissue. Therefore, whereas SIRT1 overexpression and CR both improve 
      glucose metabolism and insulin sensitivity, the etiologies of these benefits are 
      largely different.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Boutant, Marie
AU  - Boutant M
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland.
FAU - Kulkarni, Sameer S
AU  - Kulkarni SS
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland.
FAU - Joffraud, Magali
AU  - Joffraud M
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland.
FAU - Raymond, Frederic
AU  - Raymond F
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland.
FAU - Metairon, Sylviane
AU  - Metairon S
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland.
FAU - Descombes, Patrick
AU  - Descombes P
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland; Ecole 
      Polytechnique Federale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
FAU - Canto, Carles
AU  - Canto C
AD  - Nestle Institute of Health Sciences (NIHS), 1015 Lausanne, Switzerland; Ecole 
      Polytechnique Federale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic 
      address: carlos.cantoalvarez@rd.nestle.com.
LA  - eng
PT  - Journal Article
DEP - 20160225
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - EC 3.5.1.- (Sirt1 protein, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Fasting/*physiology
MH  - Gene Expression
MH  - Glucose/metabolism
MH  - Insulin Resistance
MH  - Liver/metabolism
MH  - Male
MH  - Mice, Transgenic
MH  - Muscle, Skeletal/metabolism
MH  - Physical Conditioning, Animal
MH  - Sirtuin 1/*physiology
MH  - Transcriptome
OTO - NOTNLM
OT  - SIRT1
OT  - caloric restriction
OT  - mitochondria
EDAT- 2016/03/01 06:00
MHDA- 2017/01/11 06:00
CRDT- 2016/03/01 06:00
PHST- 2015/07/14 00:00 [received]
PHST- 2015/11/03 00:00 [revised]
PHST- 2016/01/26 00:00 [accepted]
PHST- 2016/03/01 06:00 [entrez]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - S2211-1247(16)30081-X [pii]
AID - 10.1016/j.celrep.2016.02.007 [doi]
PST - ppublish
SO  - Cell Rep. 2016 Mar 8;14(9):2068-2075. doi: 10.1016/j.celrep.2016.02.007. Epub 
      2016 Feb 25.