PMID- 26923950
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20170515
IS  - 1522-7243 (Electronic)
IS  - 1522-7235 (Linking)
VI  - 31
IP  - 7
DP  - 2016 Nov
TI  - Systematical investigation of binding interaction between novel ruthenium(II) 
      arene complex with curcumin analogs and ctDNA.
PG  - 1384-1394
LID - 10.1002/bio.3119 [doi]
AB  - In this study, the interaction between a novel ruthenium(II) arene complex with 
      curcumin analogs and calf thymus DNA (ctDNA) was investigated systematically by 
      viscosity measurement, the DNA melting approach, multispectroscopic techniques 
      and electrochemical methods. The absorption spectra of the ctDNA-drug complex 
      showed a slight red shift and a weak hypochromic effect. The relative viscosity 
      and melting temperature of ctDNA increased on addition of the drug. The evidence 
      obtained from fluorescence competitive experiments indicated that the binding 
      mode of the drug with ctDNA was intercalative. Using acridine orange (AO) as a 
      fluorescence probe, the drug statically quenched the fluorescence of the ctDNA-AO 
      complex, and hydrogen bonding and van der Waals interactions played vital roles 
      in the binding interaction between the drug and ctDNA. The influences of ionic 
      strength, chemical denaturants and pH on the binding interaction were also 
      investigated. Circular dichroism and Fourier transform infrared spectra suggested 
      that this drug might bond with the G-C base pairs of ctDNA and the right-handed 
      B-form helicity of ctDNA remained after drug binding. The intercalative binding 
      between the drug and ctDNA was further investigated using electrochemical 
      techniques. All these results suggested that the biological activity of ctDNA was 
      affected by ruthenium(II) arene complex with curcumin analogs. Copyright (c) 2016 
      John Wiley & Sons, Ltd.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Huang, Shan
AU  - Huang S
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China.
AD  - Collaborative Innovation Center of Southwest Ethnic Medicine, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Liang, Yu
AU  - Liang Y
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China.
FAU - Huang, Chusheng
AU  - Huang C
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China.
AD  - Collaborative Innovation Center of Southwest Ethnic Medicine, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Su, Wei
AU  - Su W
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China.
AD  - Collaborative Innovation Center of Southwest Ethnic Medicine, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Lei, Xiaolin
AU  - Lei X
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China.
FAU - Liu, Yi
AU  - Liu Y
AD  - State Key Laboratory of Virology, Wuhan University, Wuhan, 430072, People's 
      Republic of China.
FAU - Xiao, Qi
AU  - Xiao Q
AD  - College of Chemistry and Material Science, Guangxi Teachers Education University, 
      Nanning, 530001, People's Republic of China. qi.xiao@whu.edu.cn.
AD  - Collaborative Innovation Center of Southwest Ethnic Medicine, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China. qi.xiao@whu.edu.cn.
AD  - State Key Laboratory of Virology, Wuhan University, Wuhan, 430072, People's 
      Republic of China. qi.xiao@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160229
PL  - England
TA  - Luminescence
JT  - Luminescence : the journal of biological and chemical luminescence
JID - 100889025
RN  - 0 (Coordination Complexes)
RN  - 7UI0TKC3U5 (Ruthenium)
RN  - 9007-49-2 (DNA)
RN  - 91080-16-9 (calf thymus DNA)
RN  - IT942ZTH98 (Curcumin)
RN  - J64922108F (Benzene)
SB  - IM
MH  - Animals
MH  - Benzene/chemistry
MH  - Binding Sites
MH  - Cattle
MH  - Circular Dichroism
MH  - Coordination Complexes/chemistry
MH  - Curcumin/*chemistry
MH  - DNA/*chemistry
MH  - Electrochemistry
MH  - Ruthenium/*chemistry
MH  - Viscosity
OTO - NOTNLM
OT  - calf thymus DNA
OT  - intercalative binding
OT  - ruthenium(II) arene complex with curcumin analogs
EDAT- 2016/03/01 06:00
MHDA- 2017/05/16 06:00
CRDT- 2016/03/01 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/01/17 00:00 [revised]
PHST- 2016/01/24 00:00 [accepted]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/03/01 06:00 [entrez]
AID - 10.1002/bio.3119 [doi]
PST - ppublish
SO  - Luminescence. 2016 Nov;31(7):1384-1394. doi: 10.1002/bio.3119. Epub 2016 Feb 29.