PMID- 26924584
OWN - NLM
STAT- MEDLINE
DCOM- 20170608
LR  - 20171113
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 161
DP  - 2016 Jul
TI  - Androgen-metabolizing enzymes: A structural perspective.
PG  - 54-72
LID - S0960-0760(16)30035-8 [pii]
LID - 10.1016/j.jsbmb.2016.02.021 [doi]
AB  - Androgen-metabolizing enzymes convert cholesterol, a relatively inert molecule, 
      into some of the most potent chemical messengers in vertebrates. This conversion 
      involves thermodynamically challenging reactions catalyzed by P450 enzymes and 
      redox reactions catalyzed by Aldo-Keto Reductases (AKRs). This review covers the 
      structures of these enzymes with a focus on active site interactions and proposed 
      mechanisms. Due to their role in a number of diseases, particularly in cancer, 
      androgen-metabolizing enzymes have been targets of drug design. Hence we will 
      also highlight how existing knowledge of structure is being used to this end.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Manenda, Mahder Seifu
AU  - Manenda MS
AD  - Departement de Biochimie, de Microbiologie et de Bio-informatique, PROTEO, 
      Universite Laval, Quebec City, QC G1V 0A6, Canada; Institut de Biologie 
      Integrative et des Systemes (IBIS), Universite Laval, Pavillon 
      Charles-Eugene-Marchand, Quebec City, QC G1V 0A6, Canada.
FAU - Hamel, Charles Jeremie
AU  - Hamel CJ
AD  - Departement de Biochimie, de Microbiologie et de Bio-informatique, PROTEO, 
      Universite Laval, Quebec City, QC G1V 0A6, Canada; Institut de Biologie 
      Integrative et des Systemes (IBIS), Universite Laval, Pavillon 
      Charles-Eugene-Marchand, Quebec City, QC G1V 0A6, Canada.
FAU - Masselot-Joubert, Lorelei
AU  - Masselot-Joubert L
AD  - Departement de Biochimie, de Microbiologie et de Bio-informatique, PROTEO, 
      Universite Laval, Quebec City, QC G1V 0A6, Canada; Institut de Biologie 
      Integrative et des Systemes (IBIS), Universite Laval, Pavillon 
      Charles-Eugene-Marchand, Quebec City, QC G1V 0A6, Canada.
FAU - Picard, Marie-Eve
AU  - Picard ME
AD  - Departement de Biochimie, de Microbiologie et de Bio-informatique, PROTEO, 
      Universite Laval, Quebec City, QC G1V 0A6, Canada; Institut de Biologie 
      Integrative et des Systemes (IBIS), Universite Laval, Pavillon 
      Charles-Eugene-Marchand, Quebec City, QC G1V 0A6, Canada.
FAU - Shi, Rong
AU  - Shi R
AD  - Departement de Biochimie, de Microbiologie et de Bio-informatique, PROTEO, 
      Universite Laval, Quebec City, QC G1V 0A6, Canada; Institut de Biologie 
      Integrative et des Systemes (IBIS), Universite Laval, Pavillon 
      Charles-Eugene-Marchand, Quebec City, QC G1V 0A6, Canada. Electronic address: 
      rong.shi@bcm.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160224
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Androgens)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.1.- (17-Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.- (3-Hydroxysteroid Dehydrogenases)
RN  - EC 1.3.99.6 (3-oxo-5 beta-steroid delta 4-dehydrogenase)
SB  - IM
MH  - 17-Hydroxysteroid Dehydrogenases/chemistry/*metabolism
MH  - 3-Hydroxysteroid Dehydrogenases/chemistry/*metabolism
MH  - Androgens/chemistry/*metabolism
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/chemistry/*metabolism
MH  - Humans
MH  - Metabolic Networks and Pathways
MH  - Models, Molecular
MH  - Oxidoreductases/chemistry/*metabolism
OTO - NOTNLM
OT  - AKRs
OT  - Androgen
OT  - Aromatase
OT  - Inhibitors
OT  - P450s
OT  - PDB
OT  - Structure
EDAT- 2016/03/01 06:00
MHDA- 2017/06/09 06:00
CRDT- 2016/03/01 06:00
PHST- 2015/08/15 00:00 [received]
PHST- 2016/02/15 00:00 [revised]
PHST- 2016/02/21 00:00 [accepted]
PHST- 2016/03/01 06:00 [entrez]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2017/06/09 06:00 [medline]
AID - S0960-0760(16)30035-8 [pii]
AID - 10.1016/j.jsbmb.2016.02.021 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2016 Jul;161:54-72. doi: 10.1016/j.jsbmb.2016.02.021. 
      Epub 2016 Feb 24.