PMID- 26925258
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160229
LR  - 20220318
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2016
DP  - 2016
TI  - Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical 
      Correlations.
PG  - 1628469
LID - 10.1155/2016/1628469 [doi]
LID - 1628469
AB  - Purpose. To evaluate the relationship between corneal and conjunctival epithelium 
      thickness and ocular surface clinical tests in dry eye disease (DED) patients. 
      Patients and Methods. Fifty-four patients with DED and 32 control subjects were 
      included. Each patient underwent an ocular surface evaluation using the ocular 
      surface disease index (OSDI), tear film break-up time (TBUT), corneal and 
      conjunctival staining, tear film lipid layer analysis, and Schirmer test. The 
      central corneal (CET), limbal (LET), and bulbar conjunctival epithelium thickness 
      (BET) were acquired using spectral-domain optical coherence tomography (SD-OCT). 
      Results. Compared to control subjects, mean BET was significantly thicker and 
      mean LET was significantly lower in the DED group. There was no significant 
      difference in mean CET between the two groups. The mean LET was correlated with 
      OSDI and TBUT. The inferior LET was correlated with OSDI, Schirmer I test, TBUT, 
      Oxford score, and corneal sensitivity. Mean BET was correlated with OSDI and 
      TBUT, but not with Schirmer I test and Oxford score. Conclusions. In dry eye 
      patients, a thinner limbal epithelium and a thicker bulbar conjunctival 
      epithelium were observed. These changes were correlated to the severity of dry 
      eye symptoms and tear film alterations.
FAU - Liang, Qingfeng
AU  - Liang Q
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and 
      Visual Sciences, Beijing 100005, China.
FAU - Liang, Hong
AU  - Liang H
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and 
      Visual Sciences, Beijing 100005, China; INSERM, U968, 75012 Paris, France; UPMC 
      Universite Paris 06, UMR_S 968, Institut de la Vision, 75012 Paris, France; CNRS, 
      UMR_7210, 75012 Paris, France.
FAU - Liu, Hanruo
AU  - Liu H
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and 
      Visual Sciences, Beijing 100005, China.
FAU - Pan, Zhiqiang
AU  - Pan Z
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and 
      Visual Sciences, Beijing 100005, China.
FAU - Baudouin, Christophe
AU  - Baudouin C
AD  - INSERM, U968, 75012 Paris, France; UPMC Universite Paris 06, UMR_S 968, Institut 
      de la Vision, 75012 Paris, France; CNRS, UMR_7210, 75012 Paris, France; 
      Quinze-Vingts National Ophthalmology Hospital, 75012 Paris, France; Versailles 
      Saint-Quentin-en-Yvelines University, 78000 Versailles, France.
FAU - Labbe, Antoine
AU  - Labbe A
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and 
      Visual Sciences, Beijing 100005, China; INSERM, U968, 75012 Paris, France; UPMC 
      Universite Paris 06, UMR_S 968, Institut de la Vision, 75012 Paris, France; CNRS, 
      UMR_7210, 75012 Paris, France; Quinze-Vingts National Ophthalmology Hospital, 
      75012 Paris, France; Versailles Saint-Quentin-en-Yvelines University, 78000 
      Versailles, France.
LA  - eng
PT  - Journal Article
DEP - 20160126
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC4746380
EDAT- 2016/03/01 06:00
MHDA- 2016/03/01 06:01
PMCR- 2016/01/26
CRDT- 2016/03/01 06:00
PHST- 2015/10/31 00:00 [received]
PHST- 2015/12/31 00:00 [revised]
PHST- 2015/12/31 00:00 [accepted]
PHST- 2016/03/01 06:00 [entrez]
PHST- 2016/03/01 06:00 [pubmed]
PHST- 2016/03/01 06:01 [medline]
PHST- 2016/01/26 00:00 [pmc-release]
AID - 10.1155/2016/1628469 [doi]
PST - ppublish
SO  - J Ophthalmol. 2016;2016:1628469. doi: 10.1155/2016/1628469. Epub 2016 Jan 26.