PMID- 26926169
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1528-8951 (Electronic)
IS  - 0148-0731 (Linking)
VI  - 138
IP  - 5
DP  - 2016 May
TI  - Lattice Boltzmann Simulation of Healthy and Defective Red Blood Cell Settling in 
      Blood Plasma.
PG  - 051002
LID - 10.1115/1.4032851 [doi]
AB  - In this paper, an attempt has been made to study sedimentation of a red blood 
      cell (RBC) in a plasma-filled tube numerically. Such behaviors are studied for a 
      healthy and a defective cell which might be created due to human diseases, such 
      as diabetes, sickle-cell anemia, and hereditary spherocytosis. Flow-induced 
      deformation of RBC is obtained using finite-element method (FEM), while flow and 
      fluid-membrane interaction are handled using lattice Boltzmann (LB) and immersed 
      boundary methods (IBMs), respectively. The effects of RBC properties as well as 
      its geometry and orientation on its sedimentation rate are investigated and 
      discussed. The results show that decreasing frontal area of an RBC and/or 
      increasing tube diameter results in a faster settling. Comparison of healthy and 
      diabetic cells reveals that less cell deformability leads to slower settling. The 
      simulation results show that the sicklelike and spherelike RBCs have lower 
      settling velocity as compared with a biconcave discoid cell.
FAU - Hashemi, Z
AU  - Hashemi Z
FAU - Rahnama, M
AU  - Rahnama M
FAU - Jafari, S
AU  - Jafari S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomech Eng
JT  - Journal of biomechanical engineering
JID - 7909584
SB  - IM
MH  - Anemia, Sickle Cell/blood
MH  - Biomechanical Phenomena
MH  - Blood Sedimentation
MH  - Diabetes Mellitus/blood
MH  - Erythrocyte Deformability
MH  - Erythrocyte Membrane/metabolism
MH  - Erythrocytes/*cytology/*pathology/physiology
MH  - *Finite Element Analysis
MH  - Humans
MH  - *Mechanical Phenomena
MH  - *Models, Biological
MH  - Plasma/*cytology
MH  - Spherocytes/cytology/pathology
EDAT- 2016/03/02 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/02 06:00
PHST- 2015/06/26 00:00 [received]
PHST- 2016/03/02 06:00 [entrez]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 2499052 [pii]
AID - 10.1115/1.4032851 [doi]
PST - ppublish
SO  - J Biomech Eng. 2016 May;138(5):051002. doi: 10.1115/1.4032851.