PMID- 26926369 OWN - NLM STAT- MEDLINE DCOM- 20160915 LR - 20220310 IS - 0578-1426 (Print) IS - 0578-1426 (Linking) VI - 55 IP - 3 DP - 2016 Mar TI - [The prognostic value of baseline serum free light chain in cardiac amyloidosis]. PG - 186-90 LID - 10.3760/cma.j.issn.0578-1426.2016.03.006 [doi] AB - OBJECTIVE: To analyze the prognostic value of baseline serum free light chain (sFLC) in light-chain (AL) cardiac amyloidosis. METHODS: Twenty-seven patients with AL cardiac amyloidosis were retrospectively reviewed from January 2014 to January 2015. sFLC was measured by immuoturbidimetric assay. Baseline characteristics, echocardiographic parameters and electrocardiogram data were analyzed. According to the median baseline dFLC (involved sFLC minus uninvolved sFLC), patients were categorized into either the low dFLC(307 mg/L). RESULTS: More subjects in the high dFLC group with early/late diastolic mitral velocity ratio (E/A ratio) over 2 (71.4% vs 30.8%, P=0.035), and subjects in this group had a shorter median survival time than those in the low dFLC group (3 months vs 17 months, P=0.004). A similar phenomenon for median survival time was observed when the subjects were redivided either by a new cut-off value of 180 mg/L for dFLC (low dFLC group: 17 months; high dFLC group: 4 months, P=0.014) or a kappa/lambda ratio, in which subjects with kappa type sFLC-ratio 0.065 were in the low sFLC-ratio group (17 months) and those with kappa type sFLC-ratio > 19.6 and lambda type sFLC-ratio