PMID- 26926580 OWN - NLM STAT- MEDLINE DCOM- 20161216 LR - 20220410 IS - 1873-3514 (Electronic) IS - 0028-3932 (Print) IS - 0028-3932 (Linking) VI - 84 DP - 2016 Apr TI - Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation. PG - 222-34 LID - S0028-3932(16)30047-1 [pii] LID - 10.1016/j.neuropsychologia.2016.02.021 [doi] AB - The interactive association of age and dopaminergic polymorphisms on cognitive function has been studied extensively. However, there is limited research on whether age interacts with the association between genetic polymorphisms and motor learning. We examined a group of young and older adults' performance in three motor tasks: explicit sequence learning, visuomotor adaptation, and grooved pegboard. We assessed whether individuals' motor learning and performance were associated with their age and genotypes. We selected three genetic polymorphisms: Catechol-O-Methyl Transferase (COMT val158met) and Dopamine D2 Receptor (DRD2 G>T), which are involved with dopaminergic regulation, and Brain Derived Neurotrophic Factor (BDNF val66met) that modulates neuroplasticity and has been shown to interact with dopaminergic genes. Although the underlying mechanisms of the function of these three genotypes are different, the high performance alleles of each have been linked to better learning and performance. We created a composite polygene score based on the Number of High Performance Alleles (NHPA) that each individual carried. We found several associations between genetic profile, motor performance, and sensorimotor adaptation. More importantly, we found that this association varies with age, task type, and engagement of implicit versus explicit learning processes. CI - Copyright (c) 2016 Elsevier Ltd. All rights reserved. FAU - Noohi, Fatemeh AU - Noohi F AD - School of Kinesiology, University of Michigan, 1402 Washington Heights, Ann Arbor, MI 48109, United States; Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States. Electronic address: fnoohi@umich.edu. FAU - Boyden, Nate B AU - Boyden NB AD - Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States. Electronic address: boyden@umich.edu. FAU - Kwak, Youngbin AU - Kwak Y AD - Neuroscience Program, University of Michigan, 4137 Undergraduate Science Building, 204 Washtenaw Avenue, Ann Arbor, MI 48109, United States. Electronic address: youngbin@umass.edu. FAU - Humfleet, Jennifer AU - Humfleet J AD - Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States. Electronic address: jennfleet@gmail.com. FAU - Muller, Martijn L T M AU - Muller ML AD - Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, United States. Electronic address: mtmuller@umich.edu. FAU - Bohnen, Nicolaas I AU - Bohnen NI AD - Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, United States; Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, United States; Neurology Service and GRECC, VA Ann Arbor Healthcare System, University of Michigan, 2215 Fuller Road, Ann Arbor, MI 48105, United States. Electronic address: nbohnen@umich.edu. FAU - Seidler, Rachael D AU - Seidler RD AD - School of Kinesiology, University of Michigan, 1402 Washington Heights, Ann Arbor, MI 48109, United States; Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109, United States; Neuroscience Program, University of Michigan, 4137 Undergraduate Science Building, 204 Washtenaw Avenue, Ann Arbor, MI 48109, United States; Institute of Gerontology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, United States. Electronic address: rseidler@umich.edu. LA - eng GR - P30 AG024824/AG/NIA NIH HHS/United States GR - P50 NS091856/NS/NINDS NIH HHS/United States GR - AG-024824/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160227 PL - England TA - Neuropsychologia JT - Neuropsychologia JID - 0020713 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (DRD2 protein, human) RN - 0 (Receptors, Dopamine D2) RN - 7171WSG8A2 (BDNF protein, human) RN - EC 2.1.1.6 (COMT protein, human) RN - EC 2.1.1.6 (Catechol O-Methyltransferase) SB - IM MH - Adaptation, Psychological/*physiology MH - Aged MH - Aging/genetics/physiology/*psychology MH - Brain-Derived Neurotrophic Factor/*genetics MH - Catechol O-Methyltransferase/*genetics MH - Female MH - Genotyping Techniques MH - Humans MH - Learning/*physiology MH - Mental Status Schedule MH - Neuropsychological Tests MH - Polymorphism, Single Nucleotide MH - Psychomotor Performance/physiology MH - Reaction Time MH - Receptors, Dopamine D2/*genetics MH - Young Adult PMC - PMC4849282 MID - NIHMS766274 OTO - NOTNLM OT - Aging OT - BDNF OT - COMT OT - DRD2 OT - Sequence learning OT - Visuomotor adaptation EDAT- 2016/03/02 06:00 MHDA- 2016/12/17 06:00 PMCR- 2017/04/01 CRDT- 2016/03/02 06:00 PHST- 2015/06/29 00:00 [received] PHST- 2016/02/03 00:00 [revised] PHST- 2016/02/17 00:00 [accepted] PHST- 2016/03/02 06:00 [entrez] PHST- 2016/03/02 06:00 [pubmed] PHST- 2016/12/17 06:00 [medline] PHST- 2017/04/01 00:00 [pmc-release] AID - S0028-3932(16)30047-1 [pii] AID - 10.1016/j.neuropsychologia.2016.02.021 [doi] PST - ppublish SO - Neuropsychologia. 2016 Apr;84:222-34. doi: 10.1016/j.neuropsychologia.2016.02.021. Epub 2016 Feb 27.