PMID- 26927060
OWN - NLM
STAT- MEDLINE
DCOM- 20161104
LR  - 20220317
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 3
DP  - 2016 Feb 24
TI  - Critical Overview of the Risk Scoring Systems to Predict Non-Responsiveness to 
      Intravenous Immunoglobulin in Kawasaki Syndrome.
PG  - 278
LID - 10.3390/ijms17030278 [doi]
LID - 278
AB  - Kawasaki syndrome (KS) is the most relevant cause of heart disease in children 
      living in developed countries. Intravenous immunoglobulin (IVIG) has a preventive 
      function in the formation of coronary artery abnormalities and a poor 
      strictly-curative action in established coronary damage. More than two decades 
      ago, the Harada score was set to assess which children with KS should be subject 
      to administration of IVIG, evaluating retrospectively a large cohort of patients 
      with regard to age, sex and laboratory data. Nowadays, high dose IVIG is 
      administered to all children with a confirmed diagnosis of KS, but a tool for 
      predicting non-responsiveness to the initial infusion of IVIG has not been found. 
      The prediction of IVIG resistance is a crucial issue, as recognising these 
      high-risk patients should consent the administration of an intensified initial 
      treatment in combination with IVIG in order to prevent coronary injuries. Few 
      reports have focused on factors, referring to both clinical parameters and 
      laboratory data at the onset of KS, in order to predict which patients might be 
      IVIG non-responsive. We have analysed three different risk scores which were 
      formulated to predict IVIG resistance in Japanese children with typical KS, but 
      their application in non-Japanese patients or in those with incomplete and 
      atypical patterns of the disease has been studied in a fragmentary way. Overall, 
      our analysis showed that early and definite ascertainment of likely IVIG 
      non-responders who require additional therapies reducing the development of 
      coronary artery involvement in children with KS is still a challenge.
FAU - Rigante, Donato
AU  - Rigante D
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Fondazione Policlinico 
      Universitario A. Gemelli, Rome 00168, Italy. drigante@gmail.com.
FAU - Andreozzi, Laura
AU  - Andreozzi L
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Fondazione Policlinico 
      Universitario A. Gemelli, Rome 00168, Italy. laurandreozzi@gmail.com.
FAU - Fastiggi, Michele
AU  - Fastiggi M
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Fondazione Policlinico 
      Universitario A. Gemelli, Rome 00168, Italy. micstiggi@gmail.com.
FAU - Bracci, Benedetta
AU  - Bracci B
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Fondazione Policlinico 
      Universitario A. Gemelli, Rome 00168, Italy. benedetta.bracci@gmail.com.
FAU - Natale, Marco Francesco
AU  - Natale MF
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Fondazione Policlinico 
      Universitario A. Gemelli, Rome 00168, Italy. mark000@hotmail.it.
FAU - Esposito, Susanna
AU  - Esposito S
AD  - Pediatric Highly Intensive Care Unit, Department of Pathophysiology and 
      Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan 20122, Italy. susanna.esposito@unimi.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160224
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Biomarkers/blood/metabolism
MH  - Child
MH  - Coronary Artery Disease/diagnosis/*epidemiology/prevention & control
MH  - Humans
MH  - Immunoglobulins/administration & dosage/*therapeutic use
MH  - Injections, Intravenous
MH  - Japan
MH  - Mucocutaneous Lymph Node Syndrome/diagnosis/*drug therapy/epidemiology
PMC - PMC4813142
OTO - NOTNLM
OT  - Kawasaki syndrome
OT  - coronary artery abnormalities
OT  - intravenous immunoglobulin
EDAT- 2016/03/02 06:00
MHDA- 2016/11/05 06:00
PMCR- 2016/03/01
CRDT- 2016/03/02 06:00
PHST- 2016/01/13 00:00 [received]
PHST- 2016/01/30 00:00 [revised]
PHST- 2016/02/15 00:00 [accepted]
PHST- 2016/03/02 06:00 [entrez]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2016/11/05 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - ijms17030278 [pii]
AID - ijms-17-00278 [pii]
AID - 10.3390/ijms17030278 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Feb 24;17(3):278. doi: 10.3390/ijms17030278.