PMID- 26927086
OWN - NLM
STAT- MEDLINE
DCOM- 20161104
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 17
IP  - 3
DP  - 2016 Feb 26
TI  - Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to 
      Noise-Induced Hearing Lossin Mice.
PG  - 301
LID - 10.3390/ijms17030301 [doi]
LID - 301
AB  - Connexin26 (Cx26, encoded by GJB2) mutations are the most common cause of 
      non-syndromic deafness. GJB2 is thought to be involved in noise-induced hearing 
      loss (NIHL). However, the role of Cx26 in NIHL is still obscure. To explore the 
      association between Cx26 and NIHL, we established a Cx26 knockdown (KD) mouse 
      model by conditional knockdown of Cx26 at postnatal day 18 (P18), and then we 
      observed the auditory threshold and morphologic changes in these mice with or 
      without noise exposure. The Cx26 KD mice did not exhibit substantial hearing loss 
      and hair cell degeneration, while the Cx26 KD mice with acoustic trauma 
      experienced higher hearing loss than simple noise exposure siblings and nearly 
      had no recovery. Additionally, extensive outer hair cell loss and more severe 
      destruction of the basal organ of Corti were observed in Cx26 KD mice after noise 
      exposure. These data indicate that reduced Cx26 expression in the mature mouse 
      cochlea may increase susceptibility to noise-induced hearing loss and facilitate 
      the cell degeneration in the organ of Corti.
FAU - Zhou, Xing-Xing
AU  - Zhou XX
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. star1028@126.com.
FAU - Chen, Sen
AU  - Chen S
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. cs88030067@sina.com.
FAU - Xie, Le
AU  - Xie L
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. leoxie5842@gmail.com.
FAU - Ji, Yu-Zi
AU  - Ji YZ
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. jiyuzi1987@sina.com.
FAU - Wu, Xia
AU  - Wu X
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. wuxia027@163.com.
FAU - Wang, Wen-Wen
AU  - Wang WW
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. wangwenwen@hust.edu.cn.
FAU - Yang, Qi
AU  - Yang Q
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. yangqitj@sina.com.
FAU - Yu, Jin-Tao
AU  - Yu JT
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. yujintaoly@163.com.
FAU - Sun, Yu
AU  - Sun Y
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. sunyu@hust.edu.cn.
FAU - Lin, Xi
AU  - Lin X
AD  - Department of Otolaryngology Head and Neck Surgery, Emory University School of 
      Medicine, 615 Michael Street, Whitehead Bldg Rm#543, Atlanta, GA 30322, USA. 
      xlin2@emory.edu.
FAU - Kong, Wei-Jia
AU  - Kong WJ
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Jiefang Avenue 1277, Wuhan 430022, 
      China. entwjkong@hust.edu.cn.
AD  - Institute of Otorhinolaryngology, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan 430022, China. entwjkong@hust.edu.cn.
LA  - eng
GR  - R01 DC014496/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160226
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Connexins)
RN  - 127120-53-0 (Connexin 26)
SB  - IM
MH  - Animals
MH  - Auditory Threshold
MH  - Cochlea/*metabolism/physiology
MH  - Connexin 26
MH  - Connexins/*genetics/metabolism
MH  - Disease Susceptibility
MH  - Gene Deletion
MH  - Hearing Loss, Noise-Induced/*genetics/metabolism
MH  - Mice
PMC - PMC4813165
OTO - NOTNLM
OT  - Connexin26
OT  - GJB2
OT  - noise-induced hearing loss
EDAT- 2016/03/02 06:00
MHDA- 2016/11/05 06:00
PMCR- 2016/03/01
CRDT- 2016/03/02 06:00
PHST- 2016/01/20 00:00 [received]
PHST- 2016/02/15 00:00 [revised]
PHST- 2016/02/22 00:00 [accepted]
PHST- 2016/03/02 06:00 [entrez]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2016/11/05 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - ijms17030301 [pii]
AID - ijms-17-00301 [pii]
AID - 10.3390/ijms17030301 [doi]
PST - epublish
SO  - Int J Mol Sci. 2016 Feb 26;17(3):301. doi: 10.3390/ijms17030301.