PMID- 26927185
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160301
LR  - 20200929
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 6
IP  - 1
DP  - 2016 Feb 26
TI  - The Translational Genomics Core at Partners Personalized Medicine: Facilitating 
      the Transition of Research towards Personalized Medicine.
LID - 10.3390/jpm6010010 [doi]
LID - 10
AB  - The Translational Genomics Core (TGC) at Partners Personalized Medicine (PPM) 
      serves as a fee-for-service core laboratory for Partners Healthcare researchers, 
      providing access to technology platforms and analysis pipelines for genomic, 
      transcriptomic, and epigenomic research projects. The interaction of the TGC with 
      various components of PPM provides it with a unique infrastructure that allows 
      for greater IT and bioinformatics opportunities, such as sample tracking and data 
      analysis. The following article describes some of the unique opportunities 
      available to an academic research core operating within PPM, such the ability to 
      develop analysis pipelines with a dedicated bioinformatics team and maintain a 
      flexible Laboratory Information Management System (LIMS) with the support of an 
      internal IT team, as well as the operational challenges encountered to respond to 
      emerging technologies, diverse investigator needs, and high staff turnover. In 
      addition, the implementation and operational role of the TGC in the Partners 
      Biobank genotyping project of over 25,000 samples is presented as an example of 
      core activities working with other components of PPM.
FAU - Blau, Ashley
AU  - Blau A
AD  - Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 
      02139, USA. ablau@partners.org.
FAU - Brown, Alison
AU  - Brown A
AD  - Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 
      02139, USA. abrown13@partners.org.
FAU - Mahanta, Lisa
AU  - Mahanta L
AD  - Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 
      02139, USA. lmahanta@partners.org.
FAU - Amr, Sami S
AU  - Amr SS
AD  - Partners HealthCare Personalized Medicine, 65 Landsdowne Street, Cambridge, MA 
      02139, USA. samr@partners.org.
AD  - Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA 02115, USA. samr@partners.org.
LA  - eng
PT  - Journal Article
DEP - 20160226
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC4810389
OTO - NOTNLM
OT  - academic core facility
OT  - genomics services
OT  - genotyping
OT  - seamless workflows
OT  - translational genomics core
EDAT- 2016/03/02 06:00
MHDA- 2016/03/02 06:01
PMCR- 2016/03/01
CRDT- 2016/03/02 06:00
PHST- 2015/10/21 00:00 [received]
PHST- 2016/02/04 00:00 [revised]
PHST- 2016/02/18 00:00 [accepted]
PHST- 2016/03/02 06:00 [entrez]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2016/03/02 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - jpm6010010 [pii]
AID - jpm-06-00010 [pii]
AID - 10.3390/jpm6010010 [doi]
PST - epublish
SO  - J Pers Med. 2016 Feb 26;6(1):10. doi: 10.3390/jpm6010010.