PMID- 26927288
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20181113
IS  - 1473-1150 (Electronic)
IS  - 1470-269X (Linking)
VI  - 17
IP  - 2
DP  - 2017 Mar
TI  - Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe 
      cutaneous adverse reactions in a Malay population.
PG  - 170-173
LID - 10.1038/tpj.2016.10 [doi]
AB  - Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), 
      including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and 
      drug reaction with eosinophilia and systemic symptoms (DRESS). Although 
      HLA-B*15:02 is associated with PHT-induced SJS/TEN (PHT-SJS/TEN) in Han Chinese 
      and Thais, the genetic basis for susceptibility to PHT-induced SCARs (PHT-SCAR) 
      in other populations remains unclear. We performed a case-control association 
      study by genotyping the human leukocyte antigen (HLA)-B alleles of 16 Malay 
      PHT-SCAR patients (13 SJS/TEN and 3 DRESS), 32 PHT-tolerant controls and 300 
      healthy ethnicity-matched controls. A novel genetic biomarker, HLA-B*15:13, 
      showed significant association with PHT-SJS/TEN (53.8%, 7/13 cases) (odds ratio 
      (OR) 11.28, P=0.003) and PHT-DRESS (100%, 3/3 cases) (OR 59.00, P=0.003) when 
      compared with PHT-tolerant controls (9.4%, 3/32 controls). We also confirmed 
      HLA-B*15:02 association with PHT-SJS/TEN (61.5%, 8/13 cases vs 21.9%, 7/32 
      controls; OR 5.71, P=0.016) when compared with PHT-tolerant controls. These 
      alleles may serve as markers to predict PHT-SCAR in Malays.
FAU - Chang, C-C
AU  - Chang CC
AD  - Department of Dermatology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
FAU - Ng, C-C
AU  - Ng CC
AD  - Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala 
      Lumpur, Malaysia.
FAU - Too, C-L
AU  - Too CL
AD  - Allergy and Immunology Research Center, Institute for Medical Research, Kuala 
      Lumpur, Malaysia.
FAU - Choon, S-E
AU  - Choon SE
AD  - Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru, Malaysia.
FAU - Lee, C-K
AU  - Lee CK
AD  - Pantai Hospital Cheras, Kuala Lumpur, Malaysia.
FAU - Chung, W-H
AU  - Chung WH
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospitals, Taipei, Taiwan.
FAU - Hussein, S H
AU  - Hussein SH
AD  - Department of Dermatology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
FAU - Lim, K-S
AU  - Lim KS
AD  - Division of Neurology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Murad, S
AU  - Murad S
AD  - Allergy and Immunology Research Center, Institute for Medical Research, Kuala 
      Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160301
PL  - United States
TA  - Pharmacogenomics J
JT  - The pharmacogenomics journal
JID - 101083949
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 6158TKW0C5 (Phenytoin)
SB  - IM
MH  - Anticonvulsants/*adverse effects
MH  - Case-Control Studies
MH  - Drug Hypersensitivity Syndrome/diagnosis/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-B15 Antigen/*genetics/immunology
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Odds Ratio
MH  - Pharmacogenetics
MH  - *Pharmacogenomic Variants
MH  - Phenotype
MH  - Phenytoin/*adverse effects
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stevens-Johnson Syndrome/diagnosis/*genetics/immunology
EDAT- 2016/03/02 06:00
MHDA- 2017/08/09 06:00
CRDT- 2016/03/02 06:00
PHST- 2015/07/08 00:00 [received]
PHST- 2015/11/12 00:00 [revised]
PHST- 2016/01/20 00:00 [accepted]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2016/03/02 06:00 [entrez]
AID - tpj201610 [pii]
AID - 10.1038/tpj.2016.10 [doi]
PST - ppublish
SO  - Pharmacogenomics J. 2017 Mar;17(2):170-173. doi: 10.1038/tpj.2016.10. Epub 2016 
      Mar 1.