PMID- 26927690
OWN - NLM
STAT- MEDLINE
DCOM- 20181219
LR  - 20220408
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 68
IP  - 1
DP  - 2017 Jan
TI  - Analysis of Serum Endothelial Cell-Specific Molecule 1 (Endocan) Level in Type 2 
      Diabetes Mellitus With Acute ST-Segment Elevation Myocardial Infarction and its 
      Correlation: A Pilot Study.
PG  - 74-78
AB  - Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial 
      cells, and it can be overexpressed in diabetic patients. However, little is known 
      concerning diabetic patients with acute ST-segment elevation myocardial 
      infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having 
      type 2 diabetes mellitus (T2DM) STEMI; 72 patients with DM (38 with and 34 
      without vascular disease) and 33 individuals as a control group were included. 
      There was a significant difference in serum ESM-1 level between the T2DM group 
      and the control group (P = .03). There was also a significant difference in serum 
      ESM-1 level between the T2DM with STEMI group and newly diagnosed T2DM group 
      without vascular disease (P = .01). In patients with T2DM, serum ESM-1 levels 
      correlated positively with high-sensitivity C-reactive protein levels and the 
      neutrophil to lymphocyte ratio (r = .321, P = .006 and r = .320, P = .006). Our 
      findings suggest that serum ESM-1 level may be a novel endothelial dysfunction 
      biomarker and it may be related to vascular disease in T2DM.
CI  - (c) The Author(s) 2016.
FAU - Qiu, Chong-Rong
AU  - Qiu CR
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China fuqiang@medmail.com.cn.
AD  - Xuzhou Institute of Cardiovascular Disease, Xuzhou City, Jiangsu Province, People 
      Republic of China.
FAU - Sui, Jian
AU  - Sui J
AD  - Medical College of Jiangsu University, Zhenjiang, People Republic of China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China.
FAU - Wei, Peng
AU  - Wei P
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China.
FAU - Wu, Yan
AU  - Wu Y
AD  - Medical College of Jiangsu University, Zhenjiang, People Republic of China.
FAU - Zhu, Ke
AU  - Zhu K
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China.
FAU - Lu, Yi
AU  - Lu Y
AD  - Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People Republic of 
      China.
FAU - Wan, Peng
AU  - Wan P
AD  - Medical College of Jiangsu University, Zhenjiang, People Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20160228
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Biomarkers)
RN  - 0 (ESM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteoglycans)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Endothelial Cells/metabolism
MH  - Endothelium, Vascular/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*blood
MH  - Pilot Projects
MH  - Proteoglycans/*blood
MH  - ST Elevation Myocardial Infarction/*blood/complications/*diagnosis
OTO - NOTNLM
OT  - acute ST-segment elevation myocardial infarction
OT  - biomarker
OT  - diabetes complications
OT  - endocan
OT  - endothelial cell-specific molecule 1
OT  - type 2 diabetes mellitus
EDAT- 2016/03/02 06:00
MHDA- 2018/12/20 06:00
CRDT- 2016/03/02 06:00
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2018/12/20 06:00 [medline]
PHST- 2016/03/02 06:00 [entrez]
AID - 0003319716634581 [pii]
AID - 10.1177/0003319716634581 [doi]
PST - ppublish
SO  - Angiology. 2017 Jan;68(1):74-78. doi: 10.1177/0003319716634581. Epub 2016 Feb 28.