PMID- 26929435 OWN - NLM STAT- Publisher LR - 20191120 IS - 1399-3062 (Electronic) IS - 1398-2273 (Linking) VI - 18 IP - 3 DP - 2016 Jun TI - Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab. PG - 461-465 LID - 10.1111/tid.12522 [doi] AB - Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies. CI - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Deshayes, S AU - Deshayes S AUID- ORCID: 0000-0001-8887-3233 AD - Department of Internal Medicine, CHU de Caen, Caen, France. FAU - Bouvier, N AU - Bouvier N AD - Department of Nephrology, CHU de Caen, Caen, France. FAU - Chatelet, V AU - Chatelet V AD - Department of Nephrology, CHU de Caen, Caen, France. FAU - Hurault de Ligny, B AU - Hurault de Ligny B AD - Department of Nephrology, CHU de Caen, Caen, France. FAU - Dargere, S AU - Dargere S AD - Department of Infectious Diseases, CHU de Caen, Caen, France. FAU - Bonhomme, J AU - Bonhomme J AD - Department of Microbiology, CHU de Caen, Caen, France. FAU - Bechade, C AU - Bechade C AD - Department of Nephrology, CHU de Caen, Caen, France. LA - eng PT - Case Reports DEP - 20160407 PL - Denmark TA - Transpl Infect Dis JT - Transplant infectious disease : an official journal of the Transplantation Society JID - 100883688 OTO - NOTNLM OT - Cryptococcus neoformans OT - anti-tumor necrosis factor-alpha monoclonal antibody OT - cryptococcosis OT - immune reconstitution inflammatory syndrome OT - kidney transplantation EDAT- 2016/03/02 06:00 MHDA- 2016/03/02 06:00 CRDT- 2016/03/02 06:00 PHST- 2016/01/13 00:00 [received] PHST- 2016/02/09 00:00 [revised] PHST- 2016/02/13 00:00 [accepted] PHST- 2016/03/02 06:00 [entrez] PHST- 2016/03/02 06:00 [pubmed] PHST- 2016/03/02 06:00 [medline] AID - 10.1111/tid.12522 [doi] PST - ppublish SO - Transpl Infect Dis. 2016 Jun;18(3):461-465. doi: 10.1111/tid.12522. Epub 2016 Apr 7.