PMID- 26930261
OWN - NLM
STAT- MEDLINE
DCOM- 20170728
LR  - 20210816
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 68
DP  - 2016 Jun
TI  - Further investigations of the relation between polymorphisms in sex steroid 
      related genes and autistic-like traits.
PG  - 1-5
LID - S0306-4530(16)30050-6 [pii]
LID - 10.1016/j.psyneuen.2016.02.020 [doi]
AB  - Autism spectrum disorders (ASDs) are more prevalent in boys than in girls, 
      indicating that high levels of testosterone during early development may be a 
      risk factor. Evidence for this hypothesis comes from studies showing associations 
      between fetal testosterone levels, as well as indirect measures of prenatal 
      androgenization, and ASDs and autistic-like traits (ALTs). In a recent study we 
      reported associations between ALTs and single nucleotide polymorphisms (SNPs) in 
      the genes encoding estrogen receptor 1 (ESR1), steroid-5-alpha-reductase, type 2 
      (SRD5A2) and sex hormone-binding globulin (SHBG) in a subset (n=1771) from the 
      Child and Adolescent Twin Study in Sweden (CATSS). The aim of the present study 
      was to try to replicate these findings in an additional, larger, sample of 
      individuals from the CATSS (n=10,654), as well as to analyze additional SNPs of 
      functional importance in SHBG and SRD5A2. No associations between the previously 
      associated SNPs in the genes ESR1 and SRD5A2 and ALTs could be seen in the large 
      replication sample. Still, our results show that two non-linked SNPs (rs6259 and 
      rs9901675) at the SHBG gene locus might be of importance for language impairment 
      problems in boys. The results of the present study do not point toward a major 
      role for the investigated SNPs in the genes ESR1 and SRD5A2 in ALTs, but a 
      possible influence of genetic variation in SHBG, especially for language 
      impairment problems in boys, cannot be ruled out.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Zettergren, Anna
AU  - Zettergren A
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden; Institute of Neuroscience and Physiology, Department of 
      Psychiatry and Neurochemistry, University of Gothenburg, Sweden. Electronic 
      address: anna.zettergren@neuro.gu.se.
FAU - Karlsson, Sara
AU  - Karlsson S
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden.
FAU - Hovey, Daniel
AU  - Hovey D
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden.
FAU - Jonsson, Lina
AU  - Jonsson L
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden.
FAU - Melke, Jonas
AU  - Melke J
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden.
FAU - Anckarsater, Henrik
AU  - Anckarsater H
AD  - Institute of Neuroscience and Physiology, Centre of Ethics, Law and Mental Health 
      (CELAM), University of Gothenburg, Sweden.
FAU - Lichtenstein, Paul
AU  - Lichtenstein P
AD  - Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, 
      Stockholm, Sweden.
FAU - Lundstrom, Sebastian
AU  - Lundstrom S
AD  - Institute of Neuroscience and Physiology, Centre of Ethics, Law and Mental Health 
      (CELAM), University of Gothenburg, Sweden; Institute of Neuroscience and 
      Physiology, Gillberg Neuropsychiatry Centre, University of Gothenburg, Sweden.
FAU - Westberg, Lars
AU  - Westberg L
AD  - Institute of Neuroscience and Physiology, Department of Pharmacology, University 
      of Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20160223
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (sex hormone-binding globulin receptor)
RN  - EC 1.3.99.5 (3-Oxo-5-alpha-Steroid 4-Dehydrogenase)
RN  - EC 1.3.99.5 (SRD5A2 protein, human)
SB  - IM
MH  - 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*genetics/metabolism
MH  - Adolescent
MH  - Autism Spectrum Disorder/*genetics/metabolism
MH  - Child
MH  - Estrogen Receptor alpha/*genetics/metabolism
MH  - Female
MH  - Genetic Association Studies
MH  - Humans
MH  - Male
MH  - Membrane Proteins/*genetics/metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Cell Surface/*genetics/metabolism
OTO - NOTNLM
OT  - Association
OT  - Autism spectrum disorders
OT  - Autistic-like traits
OT  - Gene
OT  - Polymorphism
OT  - Sex steroids
EDAT- 2016/03/02 06:00
MHDA- 2017/07/29 06:00
CRDT- 2016/03/02 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2016/02/19 00:00 [revised]
PHST- 2016/02/19 00:00 [accepted]
PHST- 2016/03/02 06:00 [entrez]
PHST- 2016/03/02 06:00 [pubmed]
PHST- 2017/07/29 06:00 [medline]
AID - S0306-4530(16)30050-6 [pii]
AID - 10.1016/j.psyneuen.2016.02.020 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2016 Jun;68:1-5. doi: 10.1016/j.psyneuen.2016.02.020. 
      Epub 2016 Feb 23.