PMID- 26931618
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20170915
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 107
DP  - 2016 May
TI  - Sniping the scout: Targeting the key molecules in dendritic cell functions for 
      treatment of autoimmune diseases.
PG  - 27-41
LID - S1043-6618(16)30096-2 [pii]
LID - 10.1016/j.phrs.2016.02.023 [doi]
AB  - Dendritic cells (DCs) are a power tool for manipulating immune system. They play 
      important roles in the induction of immunity as well as inducing intrathymic and 
      peripheral tolerance. After generated from stem cells in the bone marrow, DCs 
      traffic to the peripheral tissues, where they capture and process antigens, 
      express lymphocyte co-stimulators, migrate to the secondary lymph organs and 
      present the processed antigen to naive T cells to either activate or tolerize 
      them. These processes are modulated subtly and influenced by various factors. 
      Aberrant regulation of the processes may cause autoimmunity. Investigation into 
      the biology of DCs and the molecules and mechanisms that regulate them helps us 
      understanding the pathogenesis of autoimmune diseases and reveals numerous steps 
      for pharmacological manipulation. In this review, we made a sketch line of the 
      critical events of DC biology that are potential pharmacologic targets for the 
      treatment of autoimmune diseases.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Li, Xing
AU  - Li X
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, Guangzhou, China; Institute of Clinical Immunology, 
      Academy of Orthopedics, Guangdong Province, China.
FAU - Han, Yanping
AU  - Han Y
AD  - Hospital of South China Normal University, Guangzhou, China.
FAU - Sun, Erwei
AU  - Sun E
AD  - Department of Rheumatology and Immunology, The Third Affiliated Hospital of 
      Southern Medical University, Guangzhou, China; Institute of Clinical Immunology, 
      Academy of Orthopedics, Guangdong Province, China. Electronic address: 
      sunew@smu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160227
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology
MH  - Autoimmunity
MH  - Dendritic Cells/*immunology
MH  - Humans
OTO - NOTNLM
OT  - Apigenin (PubChem CID: 5280443)
OT  - Aspirin (PubChem CID: 2244)
OT  - Auranofin (PubChem CID: 24199313)
OT  - Autoimmune diseases
OT  - Butyric acid (PubChem CID: 264)
OT  - Chloroquine (PubChem CID: 2719)
OT  - Chrysin (PubChem CID: 5281607)
OT  - Cyclosporin a (PubChem CID: 5284373)
OT  - Dendritic cells
OT  - Dexamethasone (PubChem CID: 5743)
OT  - FTY720 (PubChem CID: 107969)
OT  - Fostamatinib (PubChem CID: 11671467)
OT  - Fumarates (PubChem CID: 5281069)
OT  - Glatiramer acetate (PubChem CID: 3081884)
OT  - IL-10 (PubChem CID: 146070)
OT  - Leflunomide (PubChem CID: 3899)
OT  - Mycophenolate mofetil (PubChem CID: 5281078)
OT  - N-acetyl-L-cysteine (PubChem CID: 12035)
OT  - Oenothein B (PubChem CID: 16132398)
OT  - Quercetin (PubChem CID: 5280343)
OT  - Rapamycin (PubChem CID: 5284616)
OT  - Rheumatoid arthritis
OT  - Rosiglitazone (PubChem CID: 77999)
OT  - Sanglifehrin a (PubChem CID: 5388925)
OT  - Sunitinib (PubChem CID: 5329102)
OT  - Systemic lupus erythematosus
OT  - T helper
OT  - TGF-beta (PubChem CID: 56842206)
OT  - Tacrolimus (PubChem CID: 445643)
OT  - Tofacitinib (PubChem CID: 9926791)
OT  - Trichostatin A (PubChem CID: 444732)
OT  - Triptolide (PubChem CID: 107985)
OT  - Troglitazone (PubChem CID: 5591)
OT  - Vasoactive intestinal peptide (PubChem CID: 16129679)
OT  - Vitamin D3 (PubChem CID: 5280795)
EDAT- 2016/03/05 06:00
MHDA- 2017/03/28 06:00
CRDT- 2016/03/03 06:00
PHST- 2016/02/05 00:00 [received]
PHST- 2016/02/23 00:00 [revised]
PHST- 2016/02/23 00:00 [accepted]
PHST- 2016/03/03 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
AID - S1043-6618(16)30096-2 [pii]
AID - 10.1016/j.phrs.2016.02.023 [doi]
PST - ppublish
SO  - Pharmacol Res. 2016 May;107:27-41. doi: 10.1016/j.phrs.2016.02.023. Epub 2016 Feb 
      27.