PMID- 26932172
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 37
IP  - 2
DP  - 2016 Mar-Apr
TI  - Th1/Th2/Th17 cells imbalance in patients with asthma with and without 
      psychological symptoms.
PG  - 148-56
LID - 10.2500/aap.2016.37.3928 [doi]
AB  - BACKGROUND: The prevalence of psychological symptoms such as anxiety and 
      depression among patients with asthma is high. Both asthma and psychological 
      symptoms are characterized by immune inflammation in which CD4+ T cells play a 
      role. OBJECTIVE: To investigate whether T-helper (Th) 1, Th2, and Th17 cells 
      imbalance exists in patients with asthma and with and in patients without 
      psychological symptoms. METHODS: The messenger RNA (mRNA) expression of T-box 21 
      (T-bet), GATA binding protein 3 (GATA-3), and RAR-related orphan receptor C 
      (RORC) in peripheral CD4+ T cells of 20 patients with asthma and with 
      psychological symptoms, 30 patients with asthma and without psychological 
      symptoms, and 30 healthy subjects were detected by real-time polymerase chain 
      reaction. A Luminex-based approach quantified the levels of interferon gamma (IFN-gamma), 
      tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 4, and IL-17A cytokines in 
      serum. RESULTS: The mRNA expressions of T-bet, GATA-3 and RORC were significantly 
      different among the three groups. Significant elevations of the expressions of 
      T-bet, GATA-3, and RORC mRNA were found in patients with asthma and with 
      psychological symptoms than in healthy subjects, along with the higher levels of 
      IFN-gamma, TNF-alpha, and IL-17A. Increased expressions of T-bet mRNA were found in 
      patients with asthma and with psychological symptoms but not in those without 
      psychological symptoms. However, the ratio of T-bet to GATA-3 was in balance in 
      patients with asthma and with psychological symptoms. CONCLUSION: Analysis of our 
      data revealed Th1 and Th2 cells activated in balance in the peripheral blood of 
      patients with asthma and with psychological symptoms, along with activated Th17 
      cells. This finding provided an improved understanding of the immune-inflammation 
      responses in patients with asthma and with psychological symptoms, and offered 
      information for new targeted therapy to patients with asthma and with 
      psychological symptoms.
FAU - Zhu, Min
AU  - Zhu M
AD  - Department of Respiratory and Critical Care Medicine, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Liang, Zongan
AU  - Liang Z
FAU - Wang, Ting
AU  - Wang T
FAU - Chen, Renzhi
AU  - Chen R
FAU - Wang, Gang
AU  - Wang G
FAU - Ji, Yulin
AU  - Ji Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Asthma/diagnosis/*immunology/*psychology/therapy
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Cytokines/metabolism
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Profiling
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - T-Lymphocyte Subsets/*immunology/metabolism
MH  - Th1 Cells/immunology/metabolism
MH  - Th17 Cells/immunology/metabolism
MH  - Th2 Cells/immunology/metabolism
MH  - Young Adult
EDAT- 2016/03/05 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/03 06:00
PHST- 2016/03/03 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.2500/aap.2016.37.3928 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2016 Mar-Apr;37(2):148-56. doi: 10.2500/aap.2016.37.3928.