PMID- 26932897
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160629
LR  - 20200929
IS  - 2093-0879 (Print)
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Linking)
VI  - 22
IP  - 3
DP  - 2016 Jul 30
TI  - Protective Effect of Proton Pump Inhibitor for Survival in Patients with 
      Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis.
PG  - 444-51
LID - 10.5056/jnm15192 [doi]
AB  - BACKGROUND/AIMS: The prevalence of gastroesophageal reflux disease (GERD) is high 
      in patients with idiopathic pulmonary fibrosis (IPF). GERD may cause chronic 
      microaspiration that leads to repeated subclinical lung injury, which leads to 
      pulmonary fibrosis. Although some studies have suggested that proton pump 
      inhibitors (PPI) were associated with a good prognosis in IPF, their effects 
      remain unclear. METHODS: We retrospectively reviewed 786 consecutive adult 
      patients with IPF at Seoul National University Bundang Hospital between April 
      2003 and March 2015. RESULTS: Mean duration of follow-up was 2.6 +/- 2.8 years. Of 
      the 786 patients with IPF, 107 (13.6%) were given diagnoses of GERD, and 103 
      (13.1%) died due to IPF-related pneumonia or respiratory failure. The prevalence 
      of GERD and the cumulative incidence of de novo GERD increased depending on the 
      period of follow-up in patients with IPF. Patients administered PPI for more than 
      four months had a lower IPF-related mortality rate than patients on PPI less than 
      4 months (Log-rank P -value = 0.024 in Kaplan-Meier curve). In a univariate and 
      multivariate Cox regression hazard model, younger age (hazard ratio [HR], 1.06; 
      95% CI, 1.03-1.10; P = 0.001), higher initial forced vital capacity (HR, 0.98; 
      95% CI, 0.96-0.99; P = 0.004), and longer duration of PPI use (HR, 0.97; 95% CI, 
      0.95-1.00; P = 0.022), but not a diagnosis of GERD, were significantly associated 
      with lower IPF-related mortality. CONCLUSIONS: In Korean patients with IPF, the 
      prevalence of GERD was lower than in other countries. PPI use for at least 4 
      months may have a protective effect against IPF-related mortality.
FAU - Lee, Chang Min
AU  - Lee CM
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
FAU - Lee, Dong Ho
AU  - Lee DH
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Ahn, Byung Kyu
AU  - Ahn BK
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
FAU - Hwang, Jae Jin
AU  - Hwang JJ
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
FAU - Yoon, Hyuk
AU  - Yoon H
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
FAU - Shin, Cheol Min
AU  - Shin CM
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Park, Young Soo
AU  - Park YS
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Nayoung
AU  - Kim N
AD  - Divison of Gastroenterology, Department of Internal Medicine, Seoul National 
      University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC4930299
OTO - NOTNLM
OT  - Gastroesophageal reflux
OT  - Idiopathic pulmonary fibrosis
OT  - Korea
OT  - Proton pump inhibitor
OT  - Risk factors
EDAT- 2016/03/05 06:00
MHDA- 2016/03/05 06:01
PMCR- 2016/07/01
CRDT- 2016/03/03 06:00
PHST- 2015/12/05 00:00 [received]
PHST- 2016/01/18 00:00 [revised]
PHST- 2016/01/27 00:00 [accepted]
PHST- 2016/03/03 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/03/05 06:01 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - jnm15192 [pii]
AID - jnm-22-444 [pii]
AID - 10.5056/jnm15192 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2016 Jul 30;22(3):444-51. doi: 10.5056/jnm15192.