PMID- 26936096
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180326
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 101
IP  - 4
DP  - 2017 Aug
TI  - Effects of monensin and essential oils on immunological, haematological and 
      biochemical parameters of cows during the transition period.
PG  - 791-806
LID - 10.1111/jpn.12494 [doi]
AB  - Using a model to generate experimental groups with different manifestations of 
      post-partum (p.p.) fat mobilization and ketogenesis, the effects of a dietary and 
      a medical intervention on biochemical and haematological parameters, antibody 
      titre, leucocytes subsets and function of transition cows were examined. In 
      total, 60 German Holstein cows were allocated 6 weeks antepartum (a.p.) to 3 
      high-body condition score (BCS) groups (BCS 3.95) and 1 low-BCS group (LC, BCS 
      2.77). High-BCS cows received a monensin controlled-release capsule (HC/MO) or a 
      blend of essential oils (HC/EO) or formed a control group (HC). Parameters were 
      evaluated in 3 periods (day (d) -42 until calving, 1 until 14 days in milk (DIM), 
      15 until 56 DIM). Over the course of trial, various parameters were influenced by 
      period with greatest variability next to calving. White blood cell count was 
      higher in the HC (8.42 x 10(3) /mul) and HC/EO (8.38 x 10(3) /mul) groups than in 
      the HC/MO group (6.81 x 10(3) /mul) considering the whole trial. Supplementation 
      of monensin decreased aspartate aminotransferase in comparison with the HC group 
      similar to LC treatment. Bilirubin concentration was nearly doubled in all 
      high-BCS cows in period 2. In period 3, essential oils increased 
      gamma-glutamyltransferase (80.4 Units/l) in comparison with all other groups and 
      glutamine dehydrogenase (61 Units/l) in comparison with the LC (19 Units/l) and 
      the HC/MO group (18 Units/l). Results suggest that parameters were generally 
      characterized by a high variability around calving. Based on biochemical 
      characteristics, it appeared that the HC cows seemed to have compromised 
      hepatocyte integrity when compared to the LC cows. From the immune parameters 
      investigated, the BVDV antibody response was more pronounced in HC/MO compared to 
      HC/EO.
CI  - Journal of Animal Physiology and Animal Nutrition (c) 2016 Blackwell Verlag GmbH.
FAU - Drong, C
AU  - Drong C
AD  - Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Braunschweig, Germany.
FAU - Meyer, U
AU  - Meyer U
AD  - Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Braunschweig, Germany.
FAU - von Soosten, D
AU  - von Soosten D
AD  - Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Braunschweig, Germany.
FAU - Frahm, J
AU  - Frahm J
AD  - Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Braunschweig, Germany.
FAU - Rehage, J
AU  - Rehage J
AD  - Clinic for Cattle, University of Veterinary Medicine, Foundation, Hannover, 
      Germany.
FAU - Schirrmeier, H
AU  - Schirrmeier H
AD  - Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Greifswald-Insel Riems, Germany.
FAU - Beer, M
AU  - Beer M
AD  - Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Greifswald-Insel Riems, Germany.
FAU - Danicke, S
AU  - Danicke S
AD  - Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Braunschweig, Germany.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20160302
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Oils, Volatile)
RN  - 906O0YJ6ZP (Monensin)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Cattle/*blood/physiology
MH  - Diet/veterinary
MH  - Female
MH  - Lactation/*physiology
MH  - Monensin/*pharmacology
MH  - Oils, Volatile/*pharmacology
MH  - Pregnancy
OTO - NOTNLM
OT  - metabolism
OT  - nutrition
OT  - physiology
OT  - ruminants
OT  - supplementation
EDAT- 2016/03/05 06:00
MHDA- 2018/03/27 06:00
CRDT- 2016/03/04 06:00
PHST- 2015/12/04 00:00 [received]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2016/03/04 06:00 [entrez]
AID - 10.1111/jpn.12494 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2017 Aug;101(4):791-806. doi: 10.1111/jpn.12494. 
      Epub 2016 Mar 2.