PMID- 26936185
OWN - NLM
STAT- MEDLINE
DCOM- 20170922
LR  - 20220409
IS  - 1573-2606 (Electronic)
IS  - 1389-9155 (Print)
IS  - 1389-9155 (Linking)
VI  - 17
IP  - 2
DP  - 2016 Jun
TI  - Understanding the metabolic and health effects of low-calorie sweeteners: 
      methodological considerations and implications for future research.
PG  - 187-94
LID - 10.1007/s11154-016-9344-5 [doi]
AB  - Consumption of foods, beverages, and packets containing low-calorie sweeteners 
      (LCS) has increased markedly across gender, age, race/ethnicity, weight status, 
      and socio-economic subgroups. However, well-controlled intervention studies 
      rigorously evaluating the health effects of LCS in humans are limited. One of the 
      key questions is whether LCS are indeed a beneficial strategy for weight 
      management and prevention of obesity. The current review discusses several 
      methodological considerations in the design and interpretation of these studies. 
      Specifically, we focus on the selection of study participants, inclusion of an 
      appropriate control, importance of considering habitual LCS exposure, selection 
      of specific LCS, dose and route of LCS administration, choice of study outcomes, 
      and the context and generalizability of the study findings. These critical 
      considerations will guide the design of future studies and thus assist in 
      understanding the health effects of LCS.
FAU - Sylvetsky, Allison C
AU  - Sylvetsky AC
AD  - Department of Exercise and Nutrition Sciences, The George Washington University, 
      950 New Hampshire Avenue NW, Washington, DC, 20052, USA.
AD  - Section on Pediatric Diabetes and Metabolism, NIDDK, NIH, 9000 Rockville Pike, 
      Building 10, Room 8C432A, Bethesda, MD, 20892, USA.
FAU - Blau, Jenny E
AU  - Blau JE
AD  - Section on Pediatric Diabetes and Metabolism, NIDDK, NIH, 9000 Rockville Pike, 
      Building 10, Room 8C432A, Bethesda, MD, 20892, USA.
FAU - Rother, Kristina I
AU  - Rother KI
AD  - Section on Pediatric Diabetes and Metabolism, NIDDK, NIH, 9000 Rockville Pike, 
      Building 10, Room 8C432A, Bethesda, MD, 20892, USA. kristina.rother@nih.gov.
LA  - eng
GR  - ZIA DK075093-01/Intramural NIH HHS/United States
GR  - ZIA DK075093-02/Intramural NIH HHS/United States
GR  - ZIA DK075093-03/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Endocr Metab Disord
JT  - Reviews in endocrine & metabolic disorders
JID - 100940588
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Clinical Studies as Topic/*standards
MH  - Humans
MH  - Obesity/*prevention & control
MH  - Outcome Assessment, Health Care/*standards
MH  - Sweetening Agents/administration & dosage/adverse effects/*pharmacology
PMC - PMC5010791
MID - NIHMS765511
OTO - NOTNLM
OT  - Artificial sweeteners
OT  - Beverages
OT  - Diet soda
OT  - Low-calorie sweeteners
OT  - Metabolism
OT  - Obesity
OT  - Study design
OT  - Weight
EDAT- 2016/03/05 06:00
MHDA- 2017/09/25 06:00
PMCR- 2017/06/01
CRDT- 2016/03/04 06:00
PHST- 2016/03/04 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.1007/s11154-016-9344-5 [pii]
AID - 10.1007/s11154-016-9344-5 [doi]
PST - ppublish
SO  - Rev Endocr Metab Disord. 2016 Jun;17(2):187-94. doi: 10.1007/s11154-016-9344-5.