PMID- 26937383
OWN - NLM
STAT- MEDLINE
DCOM- 20161221
LR  - 20231111
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 11
DP  - 2016
TI  - Language at rest: A longitudinal study of intrinsic functional connectivity in 
      preterm children.
PG  - 149-157
LID - S2213-1582(16)30015-8 [pii]
LID - 10.1016/j.nicl.2016.01.016 [doi]
AB  - BACKGROUND: Preterm (PT) children show early cognitive and language deficits and 
      display altered cortical connectivity for language compared to term (T) children. 
      Developmentally, functional connectivity networks become more segregated and 
      integrated, through the weakening of short-range and strengthening of long-range 
      connections. METHODS: Longitudinal intrinsic connectivity distribution (ICD) 
      values were assessed in PT (n = 13) compared to T children (n = 12) at ages 8 vs. 
      16 using a Linear Mixed Effects model. Connectivity values in regions generated 
      by the group x age interaction analysis were then correlated to scores on full IQ 
      (FSIQ), verbal IQ (VIQ), verbal comprehension IQ (VCIQ), performance IQ (PIQ), 
      Peabody picture vocabulary test-revised (PPVT-R), and Rapid Naming Composite 
      (RDRL_Cmp). RESULTS: Nine regions were generated by the group x age interaction 
      analysis. PT connectivity significantly increased over time in all but two 
      regions, and they ultimately displayed greater relative connectivity at age 16 
      than Ts in all areas except the left occipito-temporal cortex (OTC). PTs 
      underwent significant connectivity reductions in the left OTC, which corresponded 
      with worse performance on FSIQ, VIQ, and PIQ. These findings differed from Ts, 
      who did not undergo any significant changes in connectivity over time. 
      CONCLUSIONS: These findings suggest that the developmental alterations in 
      connectivity in PT children at adolescence are both pervasive and widespread. The 
      persistent and worsening cognitive and language deficits noted in the PT subjects 
      may be attributed to the loss of connections in the left OTC.
FAU - Rowlands, Megan A
AU  - Rowlands MA
AD  - Pediatrics, Yale School of Medicine, New Haven, CT, USA. Electronic address: 
      Megan.Rowlands@yale.edu.
FAU - Scheinost, Dustin
AU  - Scheinost D
AD  - Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
FAU - Lacadie, Cheryl
AU  - Lacadie C
AD  - Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
FAU - Vohr, Betty
AU  - Vohr B
AD  - Pediatrics, Warren Alpert Medical School, Brown University, Providence, RI, USA.
FAU - Li, Fangyong
AU  - Li F
AD  - Yale Center for Analytical Science, Yale School of Public Health, New Haven, CT, 
      USA.
FAU - Schneider, Karen C
AU  - Schneider KC
AD  - Pediatrics, Yale School of Medicine, New Haven, CT, USA.
FAU - Todd Constable, R
AU  - Todd Constable R
AD  - Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
FAU - Ment, Laura R
AU  - Ment LR
AD  - Pediatrics, Yale School of Medicine, New Haven, CT, USA; Neurology, Yale School 
      of Medicine, New Haven, CT, USA.
LA  - eng
GR  - P30 CA016359/CA/NCI NIH HHS/United States
GR  - R01 NS027116/NS/NINDS NIH HHS/United States
GR  - 2T35HL00764926/HL/NHLBI NIH HHS/United States
GR  - R01 NS 27116/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20160121
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - *Intelligence Tests
MH  - *Language
MH  - Longitudinal Studies
MH  - Male
MH  - Neural Pathways/*physiology
MH  - Rest/physiology
MH  - Temporal Lobe/*physiology
PMC - PMC4753807
OTO - NOTNLM
OT  - BA, Brodmann area
OT  - Development
OT  - FSIQ, full scale IQ
OT  - Functional connectivity
OT  - Intrinsic connectivity distribution
OT  - Language
OT  - OTC, occipito-temporal cortex
OT  - PIQ, performance IQ
OT  - PPVT, Peabody picture vocabulary test
OT  - PT, preterm
OT  - Preterm
OT  - RDRL_Cmp, Rapid Naming Composite
OT  - ROI, region of interest
OT  - RSC, resting state connectivity
OT  - RSN, resting state network
OT  - Resting state
OT  - T, term
OT  - VCIQ, verbal comprehension IQ
OT  - VIQ, verbal IQ
OT  - VWFA, visual word form area
EDAT- 2016/03/05 06:00
MHDA- 2016/12/22 06:00
PMCR- 2016/01/21
CRDT- 2016/03/04 06:00
PHST- 2015/08/11 00:00 [received]
PHST- 2015/12/15 00:00 [revised]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/03/04 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/12/22 06:00 [medline]
PHST- 2016/01/21 00:00 [pmc-release]
AID - S2213-1582(16)30015-8 [pii]
AID - 10.1016/j.nicl.2016.01.016 [doi]
PST - epublish
SO  - Neuroimage Clin. 2016 Jan 21;11:149-157. doi: 10.1016/j.nicl.2016.01.016. 
      eCollection 2016.