PMID- 26938545
OWN - NLM
STAT- MEDLINE
DCOM- 20161026
LR  - 20181202
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 13
IP  - 3
DP  - 2016 Feb 29
TI  - The Effect of Exposure to Persistent Organic Pollutants on Metabolic Health among 
      KOREAN Children during a 1-Year Follow-Up.
LID - 10.3390/ijerph13030270 [doi]
LID - 270
AB  - Previous evidence suggests the potential for adverse effects of persistent 
      organic pollutants (POPs) on metabolic health even at low-dose exposure levels 
      common among the general population, but there is less evidence of these 
      associations among children. Therefore, as part of a prospective cohort study, 
      214 children were measured for POPs exposure. After the 1-year follow-up, we 
      assessed the effect of circulating POPs exposure among 158 children aged 7-9 
      years (at baseline) on the change of metabolic components of metabolic syndrome 
      using multiple regression analysis. In addition, we calculated the continuous 
      metabolic syndrome (cMetS) score and assessed the variation among individuals by 
      POPs exposure. The concentrations of marker polychlorinated biphenyls (PCBs) were 
      significantly associated with increased change in diastolic blood pressure (BP) 
      and triglyceride levels during a 1-year follow-up, after controlling for sex, 
      age, household income, and change in body mass index. Total PCBs also showed a 
      marginal association with increasing cMetS score from the baseline. Of the 
      metabolic components, change in diastolic BP over time showed a notable 
      association with specific PCBs, but no association with organochlorine 
      pesticides. Here, we found that low-dose exposures to PCBs among children in the 
      general population could negatively influence metabolic health, particularly 
      diastolic BP. Increased disease sensitivity during childhood can continue to 
      adulthood, thus, these results support the need for continuous assessment of the 
      health impact of POPs.
FAU - Lee, Hye Ah
AU  - Lee HA
AD  - Department of Preventive Medicine, School of Medicine, Ewha Womans University, 
      1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea. khyeah@naver.com.
FAU - Park, Su Hyun
AU  - Park SH
AD  - Department of Preventive Medicine, School of Medicine, Ewha Womans University, 
      1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea. shp323@ewha.ac.kr.
FAU - Hong, Young Sun
AU  - Hong YS
AD  - Department of Internal Medicine, School of Medicine, Ewha Womans University, 
      1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea. imhys@ewha.ac.kr.
FAU - Ha, Eun Hee
AU  - Ha EH
AD  - Department of Preventive Medicine, School of Medicine, Ewha Womans University, 
      1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea. eunheeha@ewha.ac.kr.
FAU - Park, Hyesook
AU  - Park H
AD  - Department of Preventive Medicine, School of Medicine, Ewha Womans University, 
      1071, Anyangcheon-ro, Yangcheon-ku, Seoul 158-710, Korea. hpark@ewha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160229
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Blood Pressure/drug effects
MH  - Child
MH  - Endocrine Disruptors/*adverse effects/blood/pharmacokinetics
MH  - Environmental Exposure/*adverse effects/statistics & numerical data
MH  - Environmental Pollutants/*adverse effects/blood/pharmacokinetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Metabolic Syndrome/*chemically induced/epidemiology
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
PMC - PMC4808933
OTO - NOTNLM
OT  - children
OT  - cohort study
OT  - metabolic syndrome
OT  - persistent organic pollutants
EDAT- 2016/03/05 06:00
MHDA- 2016/10/27 06:00
PMCR- 2016/03/01
CRDT- 2016/03/04 06:00
PHST- 2015/12/31 00:00 [received]
PHST- 2016/02/14 00:00 [revised]
PHST- 2016/02/25 00:00 [accepted]
PHST- 2016/03/04 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/10/27 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - ijerph13030270 [pii]
AID - ijerph-13-00270 [pii]
AID - 10.3390/ijerph13030270 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2016 Feb 29;13(3):270. doi: 
      10.3390/ijerph13030270.