PMID- 26939369
OWN - NLM
STAT- MEDLINE
DCOM- 20160504
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 33
IP  - 11
DP  - 2015 Nov
TI  - [Simultaneous determination of four drugs for kidney diseases in urine by high 
      performance liquid chromatography].
PG  - 1210-3
AB  - A high performance liquid chromatographic (HPLC) method was proposed for the 
      simultaneous determination of four drugs for kidney disease, enalapril, 
      triamterene, furosemide and valsartan. After proteins being removed by acetone 
      precipitation method, freeze drying and redissolving in mobile phase, the urine 
      samples were analyzed by HPLC. Chromatographic separation was performed on a 
      WondaSil C18-WR (150 mm x 4.6 mm, 5 mum) in gradient elution mode using 10.0 
      mmol/L ammonium acetate aqueous solution (pH 3.90) and acetonitrile as mobile 
      phases at a flow rate of 1.0 mL/min. The detection wavelength was set at 254 nm. 
      Under the optimized conditions, good linearities were obtained in the range of 
      0.15-300 mg/L, 0.05-100 mg/L, 0.75-750 mg/L, 0.05-100 mg/L, and the detection 
      limits were 1.38 x 10(-2), 7. 67x103, 3.69x 10-2, 1. 16x 10-2 mg/L for enalapril, 
      triamterene, furosemide and valsartan, respectively. The recoveries were in the 
      range of 89.49%-99.20% with the relative standard deviations (RSDs) among 
      4.12%-9.44%. The method is simple, accurate and effective, and the results showed 
      the method is applicable for the analysis of the four drugs for kidney diseases 
      in real urine samples.
FAU - Li, Jing
AU  - Li J
FAU - Guo, Zhanchen
AU  - Guo Z
FAU - Zhao, Xu
AU  - Zhao X
FAU - Ma, Yuhua
AU  - Ma Y
FAU - Han, Ping
AU  - Han P
FAU - Feng, Shun
AU  - Feng S
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 69PN84IO1A (Enalapril)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - 80M03YXJ7I (Valsartan)
RN  - WS821Z52LQ (Triamterene)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Enalapril/*urine
MH  - Furosemide/*urine
MH  - Humans
MH  - Kidney Diseases/*drug therapy
MH  - Triamterene/*urine
MH  - Valsartan/*urine
EDAT- 2016/03/05 06:00
MHDA- 2016/05/05 06:00
CRDT- 2016/03/05 06:00
PHST- 2016/03/05 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/05/05 06:00 [medline]
AID - 10.3724/sp.j.1123.2015.07022 [doi]
PST - ppublish
SO  - Se Pu. 2015 Nov;33(11):1210-3. doi: 10.3724/sp.j.1123.2015.07022.