PMID- 26941742
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160304
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 7
DP  - 2016
TI  - Antibody Targeting of "Steady-State" Dendritic Cells Induces Tolerance Mediated 
      by Regulatory T Cells.
PG  - 63
LID - 10.3389/fimmu.2016.00063 [doi]
LID - 63
AB  - Dendritic cells (DCs) are often defined as pivotal inducers of immunity, but 
      these proinflammatory properties only develop after stimulation or ex vivo 
      manipulation of DCs. Under non-inflammatory conditions in vivo, DCs are embedded 
      into a tissue environment and encounter a plethora of self-antigens derived from 
      apoptotic material. This material is transported to secondary lymphoid organs. As 
      DCs maintain their non-activated phenotype in a sterile tissue environment, 
      interaction with T cells will induce rather regulatory T cells than effector T 
      cells. Thus, DCs are not only inducers of immunity but are also critical for 
      maintenance of peripheral tolerance. Therapeutically, intervention for the 
      induction of long-lasting tolerance in several autoimmune conditions may 
      therefore be possible by manipulating DC activation and/or targeting of DCs in 
      their "natural" tissue environment.
FAU - Mahnke, Karsten
AU  - Mahnke K
AD  - University Hospital Heidelberg, University of Heidelberg , Heidelberg , Germany.
FAU - Ring, Sabine
AU  - Ring S
AD  - University Hospital Heidelberg, University of Heidelberg , Heidelberg , Germany.
FAU - Enk, Alexander H
AU  - Enk AH
AD  - University Hospital Heidelberg, University of Heidelberg , Heidelberg , Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160223
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4763042
OTO - NOTNLM
OT  - DEC205
OT  - antibody targeting
OT  - dendritic cells
OT  - regulatory T cells
OT  - tolerance
EDAT- 2016/03/05 06:00
MHDA- 2016/03/05 06:01
PMCR- 2016/01/01
CRDT- 2016/03/05 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/02/08 00:00 [accepted]
PHST- 2016/03/05 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/03/05 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2016.00063 [doi]
PST - epublish
SO  - Front Immunol. 2016 Feb 23;7:63. doi: 10.3389/fimmu.2016.00063. eCollection 2016.