PMID- 26941808
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160304
LR  - 20200929
IS  - 1735-1995 (Print)
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 20
IP  - 11
DP  - 2015 Nov
TI  - Effects of oral vitamin E on treatment of atopic dermatitis: A randomized 
      controlled trial.
PG  - 1053-7
LID - 10.4103/1735-1995.172815 [doi]
AB  - BACKGROUND: The pathogenesis of atopic dermatitis (AD) remains to be determined; 
      recently a possible change in the immune system with production of 
      immunoglobulins is proposed. As vitamin E is a potent antioxidant, with the 
      ability to decrease the serum levels of immunoglobulin E (IgE) in atopic 
      patients, we aimed to evaluate the effect of oral vitamin E on treatment of AD. 
      MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial 
      comprised seventy participants with mild-to-moderate AD, based on the Hanifin and 
      Rajka diagnostic criteria. The patients were randomly selected from teaching skin 
      clinics in Isfahan, Iran. They were randomly assigned to two groups of equal 
      number, receiving vitamin E (400 IU/day) and placebo for four 4 months. Each 
      month, the extent, severity, and subjective symptoms including itch and 
      sleeplessness were measured by SCORAD index. Three months after the end of 
      intervention, the recurrence rate was assessed. RESULTS: The improvement in all 
      symptoms, except sleeplessness, was significantly higher in the group receiving 
      vitamin E than in controls (-1.5 vs. 0.218 in itching, -10.85 vs. -3.54 in extent 
      of lesion, and -11.12 vs. -3.89 in SCORAD index, respectively, P < 0.05). Three 
      months after the end of intervention, the recurrence rate of AD was evaluated. 
      Recurrence rate between all 42 individuals, who remained in the study, was 18.6%. 
      Recurrence ratio of the group receiving vitamin E compared to the placebo group 
      was 1.17, without significant differences between the two groups (P > 0.05). 
      CONCLUSION: This study suggests that vitamin E can improve the symptoms and the 
      quality of life in patients with AD. As vitamin E has no side effects with a 
      dosage of 400 IU/day, it can be recommended for the treatment of AD.
FAU - Jaffary, Fariba
AU  - Jaffary F
AD  - Department of Dermatology, School of Health, Skin Diseases and Leishmaniasis 
      Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Faghihi, Gita
AU  - Faghihi G
AD  - Department of Dermatology, School of Health, Skin Diseases and Leishmaniasis 
      Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Mokhtarian, Arghavan
AU  - Mokhtarian A
AD  - Skin and Stem Cell Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Hosseini, Sayed Mohsen
AU  - Hosseini SM
AD  - Department of Biostatistics and Epidemiology, School of Health, Skin Diseases and 
      Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC4755091
OTO - NOTNLM
OT  - Atopic dermatitis (AD)
OT  - SCORAD index
OT  - treatment
OT  - vitamin E
EDAT- 2016/03/05 06:00
MHDA- 2016/03/05 06:01
PMCR- 2015/11/01
CRDT- 2016/03/05 06:00
PHST- 2016/03/05 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2016/03/05 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - JRMS-20-1053 [pii]
AID - 10.4103/1735-1995.172815 [doi]
PST - ppublish
SO  - J Res Med Sci. 2015 Nov;20(11):1053-7. doi: 10.4103/1735-1995.172815.