PMID- 26943773
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20221207
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 14
DP  - 2016 Apr 5
TI  - Identification of FGF19 as a prognostic marker and potential driver gene of lung 
      squamous cell carcinomas in Chinese smoking patients.
PG  - 18394-402
LID - 10.18632/oncotarget.7817 [doi]
AB  - Comprehensive genomic characterizations of lung squamous cell carcinoma (LSCC) 
      have been performed, but the differences between smokers (S-LSCC) and never 
      smokers (NS-LSCC) are not clear, as NS-LSCC could be considered as a different 
      disease from S-LSCC. In this study we delineated genomic alterations in a cohort 
      of 21 NS-LSCC and 16 S-LSCC patients, and identified common gene mutations and 
      amplifications as previously reported. Inclusion of more NS-LSCC patients enabled 
      us to identify unreported S-LSCC- or NS-LSCC-specific alterations. Importantly, 
      an amplification region containing FGF19, FGF3, FGF4 and CCND1 was found 
      five-times more frequent in S-LSCC than in NS-LSCC. Amplification of FGF19 was 
      validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell 
      growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC 
      with clinic characteristics as smoking.
FAU - Tan, Qiang
AU  - Tan Q
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Li, Fan
AU  - Li F
AD  - State Key Laboratory of Oncogenes and Related Genes, School of Biomedical 
      Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Wang, Guan
AU  - Wang G
AD  - Genomics Center, WuXi AppTec Co., Ltd., Shanghai 200131, China.
FAU - Xia, Weiliang
AU  - Xia W
AD  - State Key Laboratory of Oncogenes and Related Genes, School of Biomedical 
      Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Li, Ziming
AU  - Li Z
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Niu, Xiaomin
AU  - Niu X
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Ji, Wenxiang
AU  - Ji W
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
AD  - State Key Laboratory of Oncogenes and Related Genes, School of Biomedical 
      Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Yuan, Hong
AU  - Yuan H
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
AD  - State Key Laboratory of Oncogenes and Related Genes, School of Biomedical 
      Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Xu, Qiang
AU  - Xu Q
AD  - Jiahui International Hospital, Shanghai 200120, China.
FAU - Luo, Qingquan
AU  - Luo Q
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
FAU - Lu, Shun
AU  - Lu S
AD  - Shanghai Lung Cancer Center, Lung Cancer Research Laboratory, Shanghai Chest 
      Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200030, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (FGF19 protein, human)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Biomarkers, Tumor/*genetics/metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/pathology
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Fibroblast Growth Factors/*genetics/metabolism
MH  - Humans
MH  - Lung Neoplasms/*genetics/metabolism/pathology
MH  - Middle Aged
MH  - Prognosis
MH  - Smoking/adverse effects/*genetics/metabolism
PMC - PMC4951296
OTO - NOTNLM
OT  - FGF19
OT  - lung squamous cell carcinomas
COIS- CONFLICTS OF INTEREST The authors declare no competing financial interests.
EDAT- 2016/03/05 06:00
MHDA- 2017/02/15 06:00
PMCR- 2016/04/05
CRDT- 2016/03/05 06:00
PHST- 2015/09/15 00:00 [received]
PHST- 2016/01/24 00:00 [accepted]
PHST- 2016/03/05 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
PHST- 2016/04/05 00:00 [pmc-release]
AID - 7817 [pii]
AID - 10.18632/oncotarget.7817 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Apr 5;7(14):18394-402. doi: 10.18632/oncotarget.7817.