PMID- 26943896
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20170209
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 43
DP  - 2016 Apr
TI  - Effects of maternal exposure to di-n-butyl phthalate during pregnancy and 
      breastfeeding on ovarian development and function of F1 female rats.
PG  - 38-43
LID - S1382-6689(16)30022-9 [pii]
LID - 10.1016/j.etap.2016.01.022 [doi]
AB  - This study aimed to investigate the effects of maternal exposure to di-n-butyl 
      phthalate (DBP) during pregnancy and breastfeeding on F1 ovarian development and 
      function. A rat model of maternal exposure to DBP during pregnancy and 
      breastfeeding was established by gavage feeding female Sprague Dawley rats with 
      0, 10, 100, or 600mg/kg/day DBP from gestational day (GD) 12 to postnatal day 
      (PND) 21. F1 offspring were weaned on PND21 and were not exposed to DBP 
      afterward. The age of vaginal opening and estrus onset, estrous cyclicity, 
      c-Kit-ligand expression on ovarian granulosa cells, and the weight of ovaries and 
      uterus of F1 female offspring were not affected, whereas serum levels of 
      estradiol and progesterone were increased significantly by maternal exposure to 
      10mg/kg/day DBP from GD12 to PND21. Although F1 ovarian function may not be 
      adversely affected by maternal exposure to DBP, the increased reproductive 
      hormone levels may interfere in F1 rat fertility.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Xie, Zuoliang
AU  - Xie Z
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Wang, Jianping
AU  - Wang J
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Dai, Fen
AU  - Dai F
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Jin, Xubing
AU  - Jin X
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Wu, Kele
AU  - Wu K
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Chen, Qiong
AU  - Chen Q
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China.
FAU - Wang, Yuhuan
AU  - Wang Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou 325027, Zhejiang 
      Province, China. Electronic address: wangqu61@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160212
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Hazardous Substances)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Breast Feeding
MH  - Dibutyl Phthalate/*toxicity
MH  - Female
MH  - Hazardous Substances/*toxicity
MH  - *Maternal Exposure
MH  - Ovary/drug effects/*growth & development
MH  - Pregnancy
MH  - Progesterone/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Di-n-butyl-phthalate
OT  - Estradiol
OT  - Estrus
OT  - Kit-ligand
OT  - Progesterone
OT  - Vaginal opening
EDAT- 2016/03/05 06:00
MHDA- 2017/02/10 06:00
CRDT- 2016/03/05 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/01/25 00:00 [revised]
PHST- 2016/01/30 00:00 [accepted]
PHST- 2016/03/05 06:00 [entrez]
PHST- 2016/03/05 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
AID - S1382-6689(16)30022-9 [pii]
AID - 10.1016/j.etap.2016.01.022 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2016 Apr;43:38-43. doi: 10.1016/j.etap.2016.01.022. 
      Epub 2016 Feb 12.