PMID- 26943967
OWN - NLM
STAT- MEDLINE
DCOM- 20160712
LR  - 20160305
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 292
DP  - 2016 Mar 15
TI  - Association of ICAM-1 (K469E) and MCP-1 -2518 A>G gene polymorphism with brain 
      abscess.
PG  - 102-7
LID - S0165-5728(16)30022-4 [pii]
LID - 10.1016/j.jneuroim.2016.01.021 [doi]
AB  - Brain abscess develops in response to a parenchymal infection. Intercellular 
      adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play 
      vital role in central nervous system (CNS) diseases. We studied ICAM-1 (K469E) 
      and MCP-1 (-2518 A>G) polymorphisms among brain abscess patients. The genotypic 
      distributions of ICAM-1 (K469E) and MCP-1 (-2518 A>G) were significantly 
      different between patients and controls. Further, patient with predisposing 
      factors, and also with culture result, we found significant association. The 
      study revealed that the polymorphisms of these molecules lead to increased 
      production, which appears to be a risk for the development of brain abscess.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Mishra, Priyanka
AU  - Mishra P
AD  - Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Prasad, Kashi Nath
AU  - Prasad KN
AD  - Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India. Electronic address: kashinprasad@gmail.com.
FAU - Singh, Kamini
AU  - Singh K
AD  - Departments of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Sahu, Rabi Narayan
AU  - Sahu RN
AD  - Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences Lucknow, India.
FAU - Ojha, Bal Krishna
AU  - Ojha BK
AD  - Department of Neurosurgery, King George Medical University, Lucknow, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160202
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Abscess/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*genetics
MH  - Male
MH  - Polymorphism, Restriction Fragment Length/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Brain abscess
OT  - ICAM-1
OT  - MCP-1
OT  - Polymorphisms
OT  - Serum level
EDAT- 2016/03/06 06:00
MHDA- 2016/07/13 06:00
CRDT- 2016/03/06 06:00
PHST- 2015/11/10 00:00 [received]
PHST- 2016/01/23 00:00 [revised]
PHST- 2016/01/31 00:00 [accepted]
PHST- 2016/03/06 06:00 [entrez]
PHST- 2016/03/06 06:00 [pubmed]
PHST- 2016/07/13 06:00 [medline]
AID - S0165-5728(16)30022-4 [pii]
AID - 10.1016/j.jneuroim.2016.01.021 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2016 Mar 15;292:102-7. doi: 10.1016/j.jneuroim.2016.01.021. Epub 
      2016 Feb 2.