PMID- 26945578
OWN - NLM
STAT- MEDLINE
DCOM- 20170113
LR  - 20170113
IS  - 1559-0291 (Electronic)
IS  - 0273-2289 (Linking)
VI  - 179
IP  - 5
DP  - 2016 Jul
TI  - Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of 
      Lipid Accumulation and Oxidative Stress.
PG  - 819-29
LID - 10.1007/s12010-016-2033-8 [doi]
AB  - Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which 
      is one of the most important chronic noncommunicable diseases. Effective and 
      feasible strategies to treat IR are still urgently needed. Previous research 
      studies reported that whole body vibration (WBV) was beneficial for IR in 
      clinical; however, its underlying mechanisms remains unknown. In the present 
      study, db/db mice were treated with WBV administration 60 min/day for 12 weeks 
      and the impaired insulin sensitivity was improved. Besides, liver steatosis was 
      also ameliorated. Further explorations revealed that WBV could reduce the 
      expression of SREBP1c and increase the expression of GSH-Px and consequently 
      suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to 
      ameliorate liver steatosis and thus improves insulin resistance in db/db mice. 
      Therefore, WBV administration is a promising treatment for individuals who 
      suffered from central obesity and IR.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
FAU - Zhai, Mingming
AU  - Zhai M
AD  - Department of Biomedical Engineering, The Fourth Military Medical University, 
      Xi'an, 710032, People's Republic of China.
FAU - Guo, Fan
AU  - Guo F
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University, 
      Xi'an, 710032, People's Republic of China.
FAU - Shi, Tengrui
AU  - Shi T
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
FAU - Liu, Jiangzheng
AU  - Liu J
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
FAU - Zhang, Xiaodi
AU  - Zhang X
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
FAU - Jing, Da
AU  - Jing D
AD  - Department of Biomedical Engineering, The Fourth Military Medical University, 
      Xi'an, 710032, People's Republic of China. jingdaasq@126.com.
FAU - Hai, Chunxu
AU  - Hai C
AD  - Department of Toxicology, the Ministry of Education Key Lab of Hazard Assessment 
      and Control in Special Operational Environment, Shanxi Provincial Key Lab of Free 
      Radical Biology and Medicine, School of Public Health, The Fourth Military 
      Medical University, Xi'an, 710032, Shaanxi, People's Republic of China. 
      cx-hai@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20160305
PL  - United States
TA  - Appl Biochem Biotechnol
JT  - Applied biochemistry and biotechnology
JID - 8208561
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism/therapy
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance/*genetics
MH  - *Lipid Metabolism
MH  - Liver/metabolism
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Oxidative Stress/*physiology
MH  - Stress, Mechanical
MH  - *Vibration
OTO - NOTNLM
OT  - Glutathione peroxidases
OT  - Insulin resistance
OT  - Liver steatosis
OT  - Oxidative stress
OT  - Whole body vibration
EDAT- 2016/03/08 06:00
MHDA- 2017/01/14 06:00
CRDT- 2016/03/07 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/02/25 00:00 [accepted]
PHST- 2016/03/07 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2017/01/14 06:00 [medline]
AID - 10.1007/s12010-016-2033-8 [pii]
AID - 10.1007/s12010-016-2033-8 [doi]
PST - ppublish
SO  - Appl Biochem Biotechnol. 2016 Jul;179(5):819-29. doi: 10.1007/s12010-016-2033-8. 
      Epub 2016 Mar 5.