PMID- 2694604
OWN - NLM
STAT- MEDLINE
DCOM- 19900309
LR  - 20220318
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 57
IP  - 4
DP  - 1989
TI  - Pharmacokinetics of intravenous immunoglobulin in neonates.
PG  - 243-8
AB  - Intravenous immunoglobulin (IVIG) may be a therapeutic adjunct to antibiotic 
      treatment of neonatal infections. We examined the pharmacokinetics and safety of 
      IVIG in human neonates. Thirty neonates with suspected sepsis were randomly 
      assigned either to a treatment (receiving either 250, 500, or 1,000 mg/kg of IVIG 
      plus antibiotics) or control (antibiotics alone) group. The 500 mg/kg dose 
      produced a rise in total IgG for greater than 8 and in group B streptococcus 
      (GBS) type-specific IgG for greater than 4-14 days. The type-specific antibody 
      elevation varied with the amount of pathogen-specific antibody and dose of IVIG. 
      Pharmacokinetic analysis suggests a Vdss of 42 ml/kg, Cl of 3.0 ml/kg/day, a 
      biphasic elimination curve, and a terminal elimination half-life of 24.2 days. No 
      toxicity was observed. These data may be valuable in determining optimal dosing 
      schedules for IVIG in treating or preventing neonatal infections.
FAU - Weisman, L E
AU  - Weisman LE
AD  - Department of Pediatrics, Uniformed Services University, Bethesda, Md.
FAU - Fischer, G W
AU  - Fischer GW
FAU - Marinelli, P
AU  - Marinelli P
FAU - Hemming, V G
AU  - Hemming VG
FAU - Pierce, J R
AU  - Pierce JR
FAU - Golden, S M
AU  - Golden SM
FAU - Peck, C C
AU  - Peck CC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bacterial Infections/drug therapy/*therapy
MH  - Female
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulin G/*analysis
MH  - Immunoglobulins/administration & dosage/adverse effects/*pharmacokinetics
MH  - Infant, Newborn
MH  - Infusions, Intravenous
MH  - Male
MH  - Randomized Controlled Trials as Topic
MH  - Streptococcus agalactiae/immunology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1111/j.1423-0410.1989.tb00836.x [doi]
PST - ppublish
SO  - Vox Sang. 1989;57(4):243-8. doi: 10.1111/j.1423-0410.1989.tb00836.x.