PMID- 26949020
OWN - NLM
STAT- MEDLINE
DCOM- 20170124
LR  - 20191210
IS  - 1976-670X (Electronic)
IS  - 1976-6696 (Print)
IS  - 1976-6696 (Linking)
VI  - 49
IP  - 4
DP  - 2016 Apr
TI  - Gene repressive mechanisms in the mouse brain involved in memory formation.
PG  - 199-200
AB  - Gene regulation in the brain is essential for long-term plasticity and memory 
      formation. Despite this established notion, the quantitative translational map in 
      the brain during memory formation has not been reported. To systematically probe 
      the changes in protein synthesis during memory formation, our recent study 
      exploited ribosome profiling using the mouse hippocampal tissues at multiple time 
      points after a learning event. Analysis of the resulting database revealed novel 
      types of gene regulation after learning. First, the translation of a group of 
      genes was rapidly suppressed without change in mRNA levels. At later time points, 
      the expression of another group of genes was downregulated through reduction in 
      mRNA levels. This reduction was predicted to be downstream of inhibition of ESR1 
      (Estrogen Receptor 1) signaling. Overexpressing Nrsn1, one of the genes whose 
      translation was suppressed, or activating ESR1 by injecting an agonist interfered 
      with memory formation, suggesting the functional importance of these findings. 
      Moreover, the translation of genes encoding the translational machineries was 
      found to be suppressed, among other genes in the mouse hippocampus. Together, 
      this unbiased approach has revealed previously unidentified characteristics of 
      gene regulation in the brain and highlighted the importance of repressive 
      controls. [BMB Reports 2016; 49(4): 199-200].
FAU - Yu, Nam-Kyung
AU  - Yu NK
AD  - Department of Biological Sciences, College of Natural Sciences, Seoul National 
      University, Seoul 08826, Korea.
FAU - Kaang, Bong-Kiun
AU  - Kaang BK
AD  - Department of Biological Sciences, College of Natural Sciences, Seoul National 
      University, Seoul 08826, Korea.
LA  - eng
PT  - News
PL  - Korea (South)
TA  - BMB Rep
JT  - BMB reports
JID - 101465334
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Conditioning, Psychological
MH  - *Gene Expression Regulation
MH  - Hippocampus/physiology
MH  - Learning
MH  - Memory/*physiology
MH  - Mice
MH  - Repressor Proteins/*metabolism
PMC - PMC4915237
EDAT- 2016/03/08 06:00
MHDA- 2017/01/25 06:00
PMCR- 2016/05/30
CRDT- 2016/03/08 06:00
PHST- 2016/03/03 00:00 [received]
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2017/01/25 06:00 [medline]
PHST- 2016/05/30 00:00 [pmc-release]
AID - 3506 [pii]
AID - BMB-49-199 [pii]
AID - 10.5483/bmbrep.2016.49.4.044 [doi]
PST - ppublish
SO  - BMB Rep. 2016 Apr;49(4):199-200. doi: 10.5483/bmbrep.2016.49.4.044.