PMID- 26949382
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160307
LR  - 20200929
IS  - 1687-4757 (Print)
IS  - 1687-4765 (Electronic)
VI  - 2016
DP  - 2016
TI  - Polymorphisms of the PPAR-gamma (rs1801282) and Its Coactivator (rs8192673) Have a 
      Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 
      Diabetes Mellitus.
PG  - 4934251
LID - 10.1155/2016/4934251 [doi]
LID - 4934251
AB  - Background. The present study was designed to clarify whether common single 
      nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated 
      Receptor-gamma (PPAR-gamma) gene (rs1801282) and the Peroxisome Proliferator-Activated 
      Receptor-gamma Coactivator-1 (PGC-1alpha) gene (rs8192673) are associated with markers of 
      carotid and coronary atherosclerosis in Caucasians with type 2 diabetes mellitus 
      (T2DM). Patients and Methods. 595 T2DM subjects and 200 control subjects were 
      enrolled in the cross-sectional study. Markers of carotid atherosclerosis were 
      assessed ultrasonographically. In 215 out of 595 subjects with T2DM, a coronary 
      computed tomography angiography (CCTA) was performed for diagnostic purposes. 
      Genotyping of either rs1801282 or rs8192673 was performed using KASPar assays. 
      Results. In our study, we demonstrated an effect of the rs1801282 on markers of 
      carotid atherosclerosis (presence of plaques) in Caucasians with T2DM in 
      univariate and in multivariable linear regression analyses. Finally, we did not 
      demonstrate any association between either rs1801282 or rs8192673 and markers of 
      coronary atherosclerosis. Conclusions. In our study, we demonstrated a minor 
      effect of the rs1801282 on markers of carotid atherosclerosis (presence of 
      plaques) in Caucasians with T2DM. Moreover, we demonstrated a minor effect of the 
      rs8192673 on CIMT progression in the 3.8-year follow-up in Caucasians with T2DM.
FAU - Pleskovic, Ales
AU  - Pleskovic A
AD  - Department of Cardiology, University Medical Centre Ljubljana, Zaloska 2, SI-1000 
      Ljubljana, Slovenia.
FAU - Santl Letonja, Marija
AU  - Santl Letonja M
AD  - Department of Radiology, General Hospital Murska Sobota, Ulica Dr. Vrbnjaka 6, 
      SI-9000 Murska Sobota, Slovenia.
FAU - Cokan Vujkovac, Andreja
AU  - Cokan Vujkovac A
AD  - Department of Internal Medicine, General Hospital Slovenj Gradec, Gosposvetska 
      Cesta 1, SI-2380 Slovenj Gradec, Slovenia.
FAU - Starcevic, Jovana Nikolajevic
AU  - Starcevic JN
AD  - Institute of Histology and Embryology, Faculty of Medicine, University in 
      Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.
FAU - Petrovic, Danijel
AU  - Petrovic D
AD  - Institute of Histology and Embryology, Faculty of Medicine, University in 
      Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia; Cardiology Outpatient 
      Department, MC Medicor, 1000 Ljubljana, Slovenia.
LA  - eng
PT  - Journal Article
DEP - 20160202
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC4754488
EDAT- 2016/03/08 06:00
MHDA- 2016/03/08 06:01
PMCR- 2016/02/02
CRDT- 2016/03/08 06:00
PHST- 2015/11/29 00:00 [received]
PHST- 2016/01/14 00:00 [accepted]
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2016/03/08 06:01 [medline]
PHST- 2016/02/02 00:00 [pmc-release]
AID - 10.1155/2016/4934251 [doi]
PST - ppublish
SO  - PPAR Res. 2016;2016:4934251. doi: 10.1155/2016/4934251. Epub 2016 Feb 2.