PMID- 26949402
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160307
LR  - 20200929
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2016
DP  - 2016
TI  - Effects of Human Umbilical Cord Mesenchymal Stem Cells on Human Trophoblast Cell 
      Functions In Vitro.
PG  - 9156731
LID - 10.1155/2016/9156731 [doi]
LID - 9156731
AB  - Trophoblast cell dysfunction is involved in many disorders during pregnancy such 
      as preeclampsia and intrauterine growth restriction. Few treatments exist, 
      however, that target improving trophoblast cell function. Human umbilical cord 
      mesenchymal stem cells (hUCMSCs) are capable of self-renewing, can undergo 
      multilineage differentiation, and have homing abilities; in addition, they have 
      immunomodulatory effects and paracrine properties and thus are a prospective 
      source for cell therapy. To identify whether hUCMSCs can regulate trophoblast 
      cell functions, we treated trophoblast cells with hUCMSC supernatant or 
      cocultured them with hUCMSCs. Both treatments remarkably enhanced the migration 
      and invasion abilities of trophoblast cells and upregulated their proliferation 
      ability. At a certain concentration, hUCMSCs also modulated hCG, PIGF, and 
      sEndoglin levels in the trophoblast culture medium. Thus, hUCMSCs have a positive 
      effect on trophoblast cellular functions, which may provide a new avenue for 
      treatment of placenta-related diseases during pregnancy.
FAU - Huang, Yajing
AU  - Huang Y
AD  - Clinical and Translational Research Center, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai 200040, China.
FAU - Wu, Yanming
AU  - Wu Y
AD  - Clinical and Translational Research Center, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai 200040, China.
FAU - Chang, Xinwen
AU  - Chang X
AD  - Clinical and Translational Research Center, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai 200040, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji 
      University School of Medicine, Shanghai 200040, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Clinical and Translational Research Center, Shanghai First Maternity and Infant 
      Hospital, Tongji University School of Medicine, Shanghai 200040, China.
FAU - Duan, Tao
AU  - Duan T
AD  - Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji 
      University School of Medicine, Shanghai 200040, China.
LA  - eng
PT  - Journal Article
DEP - 20160105
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4753693
EDAT- 2016/03/08 06:00
MHDA- 2016/03/08 06:01
PMCR- 2016/01/05
CRDT- 2016/03/08 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/08/23 00:00 [revised]
PHST- 2015/10/08 00:00 [accepted]
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2016/03/08 06:01 [medline]
PHST- 2016/01/05 00:00 [pmc-release]
AID - 10.1155/2016/9156731 [doi]
PST - ppublish
SO  - Stem Cells Int. 2016;2016:9156731. doi: 10.1155/2016/9156731. Epub 2016 Jan 5.