PMID- 26949687
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160307
LR  - 20200929
IS  - 2251-9572 (Print)
IS  - 2251-9580 (Electronic)
IS  - 2251-9572 (Linking)
VI  - 5
IP  - 2
DP  - 2016 May
TI  - Moderate Patient-Prosthesis Mismatch Has No Negative Effect on Patients' 
      Functional Status After Aortic Valve Replacement With CarboMedics Prosthesis.
PG  - e29038
LID - 10.5812/cardiovascmed.29038 [doi]
LID - e29038
AB  - BACKGROUND: Patient-prosthesis mismatch (PPM) after aortic valve replacement 
      (AVR) is the subject of continuing debate in the cardiac surgery field. 
      OBJECTIVES: The aim of this study was to evaluate the frequency and severity of 
      patient-prosthesis mismatch (PPM) and the functional status of patients 
      undergoing aortic valve replacement (AVR) using a CarboMedics prosthesis in the 
      mid-term follow up. PATIENTS AND METHODS: We retrospectively studied 66 
      consecutive patients who were referred to AVR with a CarboMedics prosthesis at 
      the Rajaie cardiovascular medical and research center, a university referral 
      hospital in Tehran, Iran. The severity of PPM as well as clinical and 
      echocardiographic parameters and the patients' New York heat association (NYHA) 
      functional classification status, operative data and postoperative complications, 
      and mortality in a mid-term (4 - 5 months) follow up period was assessed. Severe 
      PPM was defined as the effective orifice area (EOA) indexed to the patient's body 
      surface area (BSA) < 0.65 cm(2)/m(2) and moderate PPM was defined as the indexed 
      effective orifice area (IEOA) between 0.65 and 0.85 cm(2)/m(2). RESULTS: Of the 
      66 studied patients, 39 were male and 27 were female. The mean age of the 
      patients was 43 +/- 17 with a range of 6 - 76 years. Implanted sizes of the 
      CarboMedics AV prosthesis in 22 patients were 19 and 21 mm, and in 44 patients 
      were 23 and 25 mm. Eleven patients had moderate PPM (IEOA < 0.85 cm(2)/m(2)) and 
      55 of them did not have PPM (IEOA >/= 0.85 cm(2)/m(2)). There were no statistically 
      significant differences between the two groups in the echocardiographic 
      trans-aortic pressure gradients (35.6 +/- 19 vs. 23.2 +/- 16 mmHg; P = 0.061) and the 
      mean NYHA functional classification (1.10 +/- 0.3 vs. 1.01 +/- 0.10; P = 0.074) after 
      AVR in the mid-term follow up. CONCLUSIONS: Moderate PPM has no negative effect 
      on echocardiographic trans-aortic pressure gradients or the patients' NYHA 
      functional status after AVR with a CarboMedics prosthesis in the mid-term follow 
      up.
FAU - Alizadeh-Ghavidel, Alireza
AU  - Alizadeh-Ghavidel A
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Azarfarin, Rasoul
AU  - Azarfarin R
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Alizadehasl, Azin
AU  - Alizadehasl A
AD  - Echocardiography Research Center, Rajaie Cardiovascular Medical and Research 
      Center, Iran University of Medical Sciences, Tehran, IR Iran.
FAU - Sadeghpour-Tabaei, Ali
AU  - Sadeghpour-Tabaei A
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, IR Iran.
FAU - Totonchi, Ziae
AU  - Totonchi Z
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20160305
PL  - India
TA  - Res Cardiovasc Med
JT  - Research in cardiovascular medicine
JID - 101608315
PMC - PMC4756227
OTO - NOTNLM
OT  - Aortic Valve
OT  - Echocardiography
OT  - Follow-Up Studies
OT  - Heart Valve Prosthesis
EDAT- 2016/03/08 06:00
MHDA- 2016/03/08 06:01
PMCR- 2016/03/05
CRDT- 2016/03/08 06:00
PHST- 2015/04/05 00:00 [received]
PHST- 2015/09/03 00:00 [revised]
PHST- 2015/09/13 00:00 [accepted]
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2016/03/08 06:01 [medline]
PHST- 2016/03/05 00:00 [pmc-release]
AID - 10.5812/cardiovascmed.29038 [doi]
PST - epublish
SO  - Res Cardiovasc Med. 2016 Mar 5;5(2):e29038. doi: 10.5812/cardiovascmed.29038. 
      eCollection 2016 May.