PMID- 26949837
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 43
IP  - 2
DP  - 2016 Mar
TI  - Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor 
      Phenotype.
PG  - 261-7
LID - 10.1017/cjn.2015.328 [doi]
AB  - BACKGROUND: Parkinson disease (PD) presents with motor and non-motor symptoms 
      (NMS). The NMS often precede the onset of motor symptoms, but may progress 
      throughout the disease course. Tremor dominant, postural instability gait 
      difficulty (PIGD), and indeterminate phenotypes can be distinguished using 
      Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype 
      would be more likely to develop NMS, and that the non-dopamine-responsive axial 
      signs would correlate with NMS severity. METHODS: We conducted a retrospective 
      cross-sectional chart review to assess the relationship between NMS and PD motor 
      phenotypes. PD patients were administered the NMS Questionnaire, the UPDRS-III, 
      and the Mini-Mental State Examination score. The relationship between NMS burden 
      and PD subtypes was examined using linear regression models. The prevalence of 
      each NMS among difference PD motor subtypes was analyzed using chi-square test. 
      RESULTS: PD patients with more advanced disease based on their UPDRS-III had 
      higher NMS Questionnaire scores. The axial component of UPDRS-III correlated with 
      higher NMS. There was no correlation between NMS and tremor scores. There was a 
      significant correlation between PIGD score and higher NMS burden. PIGD group had 
      higher prevalence in most NMS domains when compared with tremor dominant and 
      indeterminate groups independent of disease duration and severity. CONCLUSIONS: 
      NMS profile and severity vary according to motor phenotype. We conclude that in 
      the PD population, patients with a PIGD phenotype who have more axial 
      involvement, associated with advanced disease and poor motor response, have a 
      higher risk for a higher NMS burden.
FAU - Ba, Fang
AU  - Ba F
AD  - 1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye 
      Edmonton Clinic,Edmonton,Alberta,Canada.
FAU - Obaid, Mona
AU  - Obaid M
AD  - 1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye 
      Edmonton Clinic,Edmonton,Alberta,Canada.
FAU - Wieler, Marguerite
AU  - Wieler M
AD  - 1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye 
      Edmonton Clinic,Edmonton,Alberta,Canada.
FAU - Camicioli, Richard
AU  - Camicioli R
AD  - 1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye 
      Edmonton Clinic,Edmonton,Alberta,Canada.
FAU - Martin, W R Wayne
AU  - Martin WR
AD  - 1Movement Disorder Program,Division of Neurology,University of Alberta,Kaye 
      Edmonton Clinic,Edmonton,Alberta,Canada.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gait Disorders, Neurologic/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Parkinson Disease/*complications
MH  - Phenotype
MH  - Postural Balance
MH  - Retrospective Studies
MH  - Tremor/etiology
OTO - NOTNLM
OT  - Parkinson's disease
OT  - motor subtype
OT  - non-motor symptoms
EDAT- 2016/03/08 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/08 06:00
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0317167115003285 [pii]
AID - 10.1017/cjn.2015.328 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2016 Mar;43(2):261-7. doi: 10.1017/cjn.2015.328.