PMID- 26950571
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20190221
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 25
IP  - 8
DP  - 2016 Aug
TI  - Comparison of the Deep Optic Nerve Structures in Superior Segmental Optic Nerve 
      Hypoplasia and Primary Open-Angle Glaucoma.
PG  - 648-56
LID - 10.1097/IJG.0000000000000396 [doi]
AB  - PURPOSE: The purpose of this study was to characterize the microstructure of the 
      deep optic nerve tissues in eyes with superior segmental optic nerve hypoplasia 
      (SSOH) in comparison with that in primary open-angle glaucoma (POAG). METHODS: 
      Thirty-five eyes with SSOH, 37 eyes with POAG, and 54 healthy control eyes 
      underwent enhanced depth imaging (EDI) volume scanning of the optic nerve using 
      spectral-domain optical coherence tomography (SD-OCT). POAG patients were matched 
      with SSOH patients in terms of the thickness of the neuroretinal rim and the 
      retinal nerve fiber layer in the superior sector. The lamina cribrosa thickness 
      (LCT) was determined in 3 equidistant planes, and anterior lamina cribrosa 
      surface depth (LCD) was determined in 5 equidistant planes. The measurements were 
      compared between groups, and the areas under the receiver operating 
      characteristic curves (AUC) were obtained for each parameter. RESULTS: Eyes with 
      SSOH had larger LCT and smaller LCD than POAG eyes at all locations (all 
      P<0.001). The largest LCT was observed at the superior midperiphery in the SSOH 
      group, but at central locations in both the POAG and control groups. The best 
      parameters for discriminating the SSOH from glaucoma and healthy eyes were the 
      superior midperipheral LCT (AUC=0.973) and inferior and inferior midperipheral 
      LCD (AUCs=0.906), respectively. CONCLUSIONS: The LCT and LCD exhibited 
      characteristic features in eyes with SSOH that were distinctive from those of 
      POAG and healthy eyes. Investigation of the deep optic nerve structure using EDI 
      SD-OCT may be beneficial for differentiating between SSOH and glaucoma, which may 
      help to avoid both overtreatment and undertreatment.
FAU - Lee, Eun Ji
AU  - Lee EJ
AD  - Department of Ophthalmology, Seoul National University Bundang Hospital, 
      Seongnam, Korea.
FAU - Lee, Kyoung Min
AU  - Lee KM
FAU - Lee, Seung Hyen
AU  - Lee SH
FAU - Kim, Tae-Woo
AU  - Kim TW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Female
MH  - Glaucoma, Open-Angle/diagnostic imaging/*pathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/pathology
MH  - Optic Nerve/diagnostic imaging/*pathology
MH  - Optic Nerve Diseases/diagnostic imaging/*pathology
MH  - ROC Curve
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
EDAT- 2016/03/08 06:00
MHDA- 2017/10/11 06:00
CRDT- 2016/03/08 06:00
PHST- 2016/03/08 06:00 [entrez]
PHST- 2016/03/08 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
AID - 10.1097/IJG.0000000000000396 [doi]
PST - ppublish
SO  - J Glaucoma. 2016 Aug;25(8):648-56. doi: 10.1097/IJG.0000000000000396.