PMID- 26951256
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20181113
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 35
IP  - 6
DP  - 2016 Jun
TI  - The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis 
      in patients from Central Mexico.
PG  - 1457-62
LID - 10.1007/s10067-016-3223-z [doi]
AB  - Rheumatoid arthritis (RA) is a complex genetic disease. Human leukocyte antigen 
      (HLA) and non-HLA genes are reportedly associated with an increased risk of RA. 
      The protein tyrosine phosphatase non-receptor 22 gene (PTPN22), which encodes the 
      lymphoid tyrosine phosphatase (LYP) protein, is one of the best examples of a 
      non-HLA gene associated with a risk for RA in several populations. The functional 
      PTPN22 C1858T (R620W) non-synonymous polymorphism is widely associated with an 
      increased risk for RA in Europeans and non-Europeans. The aim of this study was 
      to determine if the PTPN22 C1858T polymorphism confers susceptibility to RA in a 
      sample of patients from Mexico. This study included 364 RA patients and 387 
      non-related controls from Central Mexico. Genotyping of the PTPN22 C1858T 
      (rs2476601) polymorphism was performed using allelic discrimination assays with 
      TaqMan probes. The functional PTPN22 C1858T polymorphism was associated with an 
      increased risk for RA in our study population. The CC vs CT genotype in RA 
      patients versus healthy controls had an odds ratio (OR) of 4.17 (95 % CI 
      1.79-9.74, p = 0.00036), while T allele had an OR of 4.06 (95 % CI 1.75-9.41, 
      p = 0.00043). PTPN22 is a genetic risk factor for developing RA in the Mexican 
      population.
FAU - Rincon, J F Mendoza
AU  - Rincon JF
AD  - Laboratorio de Oncologia Molecular, Unidad de Diferenciacion Celular y Cancer, 
      FES-Zaragoza, UNAM, Mexico City, Mexico.
FAU - Cano, D Lopez
AU  - Cano DL
AD  - Laboratory of Genomic Medicine, Research Unit, Hospital Juarez de Mexico, Av. 
      Instituto Politecnico Nacional No. 5160, Delegacion Gustavo A. Madero, C.P. 
      07760, Mexico City, Mexico.
AD  - Licenciatura en QFBT, Universidad del Valle de Mexico-Chapultepec, Mexico City, 
      Mexico.
FAU - Morales, S Jimenez
AU  - Morales SJ
AD  - Laboratorio de Genomica del Cancer, Instituto Nacional de Medicina Genomica, 
      Mexico City, Mexico.
FAU - Jimenez, M L Rivas
AU  - Jimenez ML
AD  - Servicio de Reumatologia, Hospital Regional Lic. Adolfo Lopez Mateos, Mexico 
      City, Mexico.
FAU - Cobos, R E Barbosa
AU  - Cobos RE
AD  - Servicio de Reumatologia, Hospital Juarez de Mexico, Mexico City, Mexico.
FAU - Bello, J Ramirez
AU  - Bello JR
AD  - Laboratory of Genomic Medicine, Research Unit, Hospital Juarez de Mexico, Av. 
      Instituto Politecnico Nacional No. 5160, Delegacion Gustavo A. Madero, C.P. 
      07760, Mexico City, Mexico. dr.julian.ramirez.hjm@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160307
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/*epidemiology/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - PTPN22
OT  - Rheumatoid arthritis
OT  - Single nucleotide polymorphism
OT  - Susceptibility
EDAT- 2016/03/10 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/03/09 06:00
PHST- 2015/12/23 00:00 [received]
PHST- 2016/02/21 00:00 [accepted]
PHST- 2016/02/10 00:00 [revised]
PHST- 2016/03/09 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - 10.1007/s10067-016-3223-z [pii]
AID - 10.1007/s10067-016-3223-z [doi]
PST - ppublish
SO  - Clin Rheumatol. 2016 Jun;35(6):1457-62. doi: 10.1007/s10067-016-3223-z. Epub 2016 
      Mar 7.