PMID- 26951533
OWN - NLM
STAT- MEDLINE
DCOM- 20170207
LR  - 20181202
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 26
IP  - 5
DP  - 2016 Aug 4
TI  - Capillary nonperfusion by novel technology of OCT angiography in a patient with 
      sickle cell disease with normal fluorescein angiogram.
PG  - e121-3
LID - 9D25C661-EC1F-47D1-8A24-B27CD2AFE88B [pii]
LID - 10.5301/ejo.5000765 [doi]
AB  - PURPOSE: Retinal ischemia is a pathophysiologic feature of sickle cell 
      retinopathy. Inner retinal thinning of retina temporal to the fovea has been 
      reported on spectral-domain optical coherence tomography (SD-OCT) even though 
      clinical examination is normal and fluorescein angiography (FA) does not show any 
      capillary dropout. In a patient with sickle cell disease with temporal inner 
      retinal thinning on SD-OCT and normal FA, the new technology of OCT angiography 
      (OCTA) showed a corresponding area of nonperfusion. METHODS: The patient with 
      sickle cell disease underwent visual acuity testing, refraction, slit-lamp 
      biomicroscopy, and dilated fundus examination. The patient also underwent SD-OCT, 
      digital FA, and OCTA. The findings are described in this case report. RESULTS: In 
      this patient with sickle cell disease, although clinical examination was normal 
      and FA did not show any capillary dropout, the SD-OCT showed inner retinal 
      thinning temporal to the fovea. Corresponding to this area, OCTA showed an area 
      of nonperfusion. CONCLUSIONS: Optical coherence tomography angiography technology 
      may be more sensitive than the gold standard FA in identifying retinal ischemia 
      in patients with sickle cell disease.
FAU - Grover, Sandeep
AU  - Grover S
AD  - Department of Ophthalmology, University of Florida College of 
      Medicine-Jacksonville, FL - USA.
FAU - Sambhav, Kumar
AU  - Sambhav K
AD  - Department of Ophthalmology, University of Florida College of 
      Medicine-Jacksonville, FL - USA.
FAU - Chalam, Kakarla V
AU  - Chalam KV
AD  - Department of Ophthalmology, University of Florida College of 
      Medicine-Jacksonville, FL - USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160804
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Anemia, Sickle Cell/*diagnostic imaging/physiopathology
MH  - Capillaries
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Ischemia/*diagnostic imaging/physiopathology
MH  - Male
MH  - Retinal Artery/*diagnostic imaging/physiopathology
MH  - Retinal Artery Occlusion/*diagnostic imaging/physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2016/03/10 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/03/09 06:00
PHST- 2016/01/27 00:00 [accepted]
PHST- 2016/03/09 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
AID - 9D25C661-EC1F-47D1-8A24-B27CD2AFE88B [pii]
AID - 10.5301/ejo.5000765 [doi]
PST - epublish
SO  - Eur J Ophthalmol. 2016 Aug 4;26(5):e121-3. doi: 10.5301/ejo.5000765.