PMID- 26951539
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20170131
IS  - 1880-4233 (Electronic)
IS  - 1340-6868 (Linking)
VI  - 23
IP  - 6
DP  - 2016 Nov
TI  - Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor 
      growth in mammary gland carcinoma.
PG  - 820-829
AB  - Cancer is a group of cells which grow in an uncontrolled manner and invades to 
      the adjacent organs to form malignant tumors. Tumor hypoxia results due to 
      contrast between the cellular oxygen expenditure and oxygen supply to the cells. 
      Hypoxia inducible factor (HIF) is a heterodimeric transcription factor encompass 
      of oxygen sensitive alpha subunit and constitutively expressed beta subunit both of 
      which are basic helix-loop-helix protein. The stability of HIF is primarily 
      regulated by post translational prolyl hydroxylation, catalyzed by prolyl 
      hydroxylase 2 (Phd-2). Phd-2 is a group of enzymes that acts as an oxygen sensor. 
      Cancer cells have altered metabolism as they fulfil their energy needs through 
      glycolysis and lipid biogenesis. HIF-1alpha is known to upregulate glycolysis by 
      activating the transcription of enzymes on the glycolytic pathway and through 
      lipogenesis. Cancer cells have over expressed fatty acid synthase owing to 
      altered glycolytic pathway. Considering the above, it is hypothesized that 
      chemical activation of Phd-2 can curtail down HIF-1alpha and subsequently fatty acid 
      synthase expression.
FAU - Singh, Manjari
AU  - Singh M
AD  - Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, 
      Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, 
      Raebareli Road, Lucknow, 226025, India.
FAU - Devi, Uma
AU  - Devi U
AD  - Department of Pharmaceutical Sciences, Faculty of Health Medical Sciences 
      Indigenous and Alternative Medicine, SHIATS-Deemed to be University, Naini, 
      Allahabad, Uttar Pradesh, India.
FAU - Roy, Subhadeep
AU  - Roy S
AD  - Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, 
      Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, 
      Raebareli Road, Lucknow, 226025, India.
FAU - Gupta, Pushpraj S
AU  - Gupta PS
AD  - Department of Pharmaceutical Sciences, Faculty of Health Medical Sciences 
      Indigenous and Alternative Medicine, SHIATS-Deemed to be University, Naini, 
      Allahabad, Uttar Pradesh, India.
FAU - Saraf, Shubhini A
AU  - Saraf SA
AD  - Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, 
      Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, 
      Raebareli Road, Lucknow, 226025, India.
FAU - Kaithwas, Gaurav
AU  - Kaithwas G
AD  - Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, 
      Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, 
      Raebareli Road, Lucknow, 226025, India. gauravpharm@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160307
PL  - Japan
TA  - Breast Cancer
JT  - Breast cancer (Tokyo, Japan)
JID - 100888201
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - EC 1.14.11.2 (EGLN1 protein, human)
RN  - EC 1.14.11.29 (Hypoxia-Inducible Factor-Proline Dioxygenases)
RN  - EC 2.3.1.85 (FASN protein, human)
RN  - EC 2.3.1.85 (Fatty Acid Synthase, Type I)
SB  - IM
MH  - Breast Neoplasms/*metabolism/*pathology
MH  - Cell Hypoxia
MH  - Fatty Acid Synthase, Type I/*antagonists & inhibitors/metabolism
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Fatty acid synthase
OT  - Hypoxia
OT  - Hypoxia inducible factor
OT  - Normoxia
OT  - Prolyl hydoxylase
EDAT- 2016/10/28 06:00
MHDA- 2017/02/01 06:00
CRDT- 2016/03/09 06:00
PHST- 2015/12/01 00:00 [received]
PHST- 2016/02/24 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
PHST- 2016/03/09 06:00 [entrez]
AID - 10.1007/s12282-016-0683-6 [pii]
AID - 10.1007/s12282-016-0683-6 [doi]
PST - ppublish
SO  - Breast Cancer. 2016 Nov;23(6):820-829. doi: 10.1007/s12282-016-0683-6. Epub 2016 
      Mar 7.