PMID- 26954016
OWN - NLM
STAT- MEDLINE
DCOM- 20170303
LR  - 20170303
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 20
IP  - 5
DP  - 2016 May
TI  - Association Between the Transforming Growth Factor Beta 1 Gene Polymorphisms and 
      Turkish Patients with Nonsyndromic Cleft Lip With/Without Cleft Palate.
PG  - 265-8
LID - 10.1089/gtmb.2015.0301 [doi]
AB  - OBJECTIVE: To examine transforming growth factor beta 1 (TGFbeta1) gene 
      polymorphisms in Turkish patients with nonsyndromic cleft lip with/without cleft 
      palate (nsCL/P). METHODS: A total of 205 Turkish subjects were included; 
      80 nsCL/P patients and 125 unrelated control individuals. Analysis of gene 
      polymorphisms was carried out by polymerase chain reaction and DNA sequencing. 
      RESULTS: We found the substitution of a proline by a leucine at codon 10 
      (Pro10Leu) and the substitution of an arginine by a proline at codon 25 
      (Arg25Pro) in exon 1 of the TGFbeta1 gene in nsCL/P patients. CONCLUSION: This is 
      the first report investigating prevalence of TGFbeta1 polymorphisms in Turkish 
      patients with nsCL/P.
FAU - Oner, Deniz Aslar
AU  - Oner DA
AD  - Department of Biology, Faculty of Science, Gazi University , Ankara, Turkey .
FAU - Tastan, Hakki
AU  - Tastan H
AD  - Department of Biology, Faculty of Science, Gazi University , Ankara, Turkey .
LA  - eng
PT  - Journal Article
DEP - 20160308
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 94ZLA3W45F (Arginine)
RN  - 9DLQ4CIU6V (Proline)
RN  - GMW67QNF9C (Leucine)
SB  - IM
MH  - Amino Acid Substitution
MH  - Arginine/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cleft Lip/complications/*genetics
MH  - Cleft Palate/complications/*genetics
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leucine/genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Proline/genetics
MH  - Transforming Growth Factor beta1/*genetics
MH  - Turkey
EDAT- 2016/03/10 06:00
MHDA- 2017/03/04 06:00
CRDT- 2016/03/09 06:00
PHST- 2016/03/09 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2017/03/04 06:00 [medline]
AID - 10.1089/gtmb.2015.0301 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2016 May;20(5):265-8. doi: 10.1089/gtmb.2015.0301. 
      Epub 2016 Mar 8.