PMID- 26954342
OWN - NLM
STAT- MEDLINE
DCOM- 20161214
LR  - 20161230
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 81
DP  - 2016 May
TI  - Cyclosporin A significantly improves preeclampsia signs and suppresses 
      inflammation in a rat model.
PG  - 77-81
LID - S1043-4666(16)30038-2 [pii]
LID - 10.1016/j.cyto.2016.02.014 [doi]
AB  - Preeclampsia is associated with an increased inflammatory response. Immune 
      suppression might be an effective treatment. The aim of this study was to examine 
      whether Cyclosporin A (CsA), an immunosuppressant, improves clinical 
      characteristics of preeclampsia and suppresses inflammation in a 
      lipopolysaccharide (LPS) induced preeclampsia rat model. Pregnant rats were 
      randomly divided into 4 groups: group 1 (PE) rats each received LPS via tail vein 
      on gestational day (GD) 14; group 2 (PE+CsA5) rats were pretreated with LPS (1.0 
      mug/kg) on GD 14 and were then treated with CsA (5mg/kg, ip) on GDs 16, 17 and 18; 
      group 3 (PE+CsA10) rats were pretreated with LPS (1.0 mug/kg) on GD 14 and were 
      then treated with CsA (10mg/kg, ip) on GDs 16, 17 and 18; group 4 (pregnant 
      control, PC) rats were treated with the vehicle (saline) used for groups 1, 2 and 
      3. Systolic blood pressure, urinary albumin, biometric parameters and the levels 
      of serum cytokines were measured on day 20. CsA treatment significantly reduced 
      LPS-induced systolic blood pressure and the mean 24-h urinary albumin excretion. 
      Pro-inflammatory cytokines IL-6, IL-17, IFN-gamma and TNF-alpha were increased in the LPS 
      treatment group but were reduced in (LPS+CsA) group (P<0.05). Anti-inflammatory 
      cytokine IL-4 was decreased in the LPS group but was increased in (LPS+CsA) group 
      (P<0.05). Cyclosporine A improved preeclampsia signs and attenuated inflammatory 
      responses in the LPS induced preeclampsia rat model which suggests that 
      immunosuppressant might be an alternative management option for preeclampsia.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Hu, Bihui
AU  - Hu B
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China; Guangzhou Medical University, Guangzhou, China; The Maternal 
      and Child Health Hospital of HuaDu District, Guangzhou, China.
FAU - Yang, Jinying
AU  - Yang J
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China; Guangzhou Medical University, Guangzhou, China.
FAU - Huang, Qian
AU  - Huang Q
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China; Guangzhou Medical University, Guangzhou, China.
FAU - Bao, Junjie
AU  - Bao J
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China; Guangzhou Medical University, Guangzhou, China.
FAU - Brennecke, Shaun Patrick
AU  - Brennecke SP
AD  - Department Perinatal Medicine Pregnancy Research Centre and University of 
      Melbourne, Department of Obstetrics and Gynecology, Royal Women's Hospital, 
      Parkville, Victoria, Australia.
FAU - Liu, Huishu
AU  - Liu H
AD  - Department of Obstetrics, Guangzhou Women and Children's Medical Center, 
      Guangzhou, China; Guangzhou Medical University, Guangzhou, China. Electronic 
      address: huishuliu@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160305
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cyclosporine/*pharmacology
MH  - Female
MH  - Fetal Weight/drug effects
MH  - Gestational Age
MH  - Immunosuppressive Agents/pharmacology
MH  - Inflammation/metabolism/*prevention & control
MH  - Interferon-gamma/blood
MH  - Interleukin-17/blood
MH  - Interleukin-6/blood
MH  - Lipopolysaccharides
MH  - Male
MH  - Pre-Eclampsia/chemically induced/metabolism/*prevention & control
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Cyclosporin A
OT  - Cytokines
OT  - Immunosuppressive therapy
OT  - Preeclampsia
EDAT- 2016/03/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/03/09 06:00
PHST- 2015/10/07 00:00 [received]
PHST- 2016/02/25 00:00 [revised]
PHST- 2016/02/25 00:00 [accepted]
PHST- 2016/03/09 06:00 [entrez]
PHST- 2016/03/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1043-4666(16)30038-2 [pii]
AID - 10.1016/j.cyto.2016.02.014 [doi]
PST - ppublish
SO  - Cytokine. 2016 May;81:77-81. doi: 10.1016/j.cyto.2016.02.014. Epub 2016 Mar 5.